10.3389/fmicb.2019.01897.s002
Elena Shevtsova
Elena
Shevtsova
Gilles Vergnaud
Gilles
Vergnaud
Alexandr Shevtsov
Alexandr
Shevtsov
Alexandr Shustov
Alexandr
Shustov
Kalysh Berdimuratova
Kalysh
Berdimuratova
Kasim Mukanov
Kasim
Mukanov
Marat Syzdykov
Marat
Syzdykov
Andrey Kuznetsov
Andrey
Kuznetsov
Larissa Lukhnova
Larissa
Lukhnova
Uinkul Izbanova
Uinkul
Izbanova
Maxim Filipenko
Maxim
Filipenko
Yerlan Ramankulov
Yerlan
Ramankulov
Table_2_Genetic Diversity of Brucella melitensis in Kazakhstan in Relation to World-Wide Diversity.xlsx
Frontiers
2019
Brucella melitensis
Kazakhstan
genotyping
genetic diversity
multiple-locus variable-number tandem repeat (VNTR) analysis (MLVA)
2019-08-13 08:18:28
Dataset
https://frontiersin.figshare.com/articles/dataset/Table_2_Genetic_Diversity_of_Brucella_melitensis_in_Kazakhstan_in_Relation_to_World-Wide_Diversity_xlsx/9575747
<p>We describe the genetic diversity of 1327 Brucella strains from human patients in Kazakhstan using multiple-locus variable-number tandem repeat (VNTR) analysis (MLVA). All strains were assigned to the Brucella melitensis East Mediterranean group and clustered into 16 MLVA11 genotypes, nine of which are reported for the first time. MLVA11 genotype 116 predominates (86.8%) and is present all over Kazakhstan indicating existence and temporary preservation of a “founder effect” among B. melitensis strains circulating in Central Eurasia. The diversity pattern observed in humans is highly similar to the pattern previously reported in animals. The diversity observed by MLVA suggested that the epidemiological status of brucellosis in Kazakhstan is the result of the introduction of a few lineages, which have subsequently diversified at the most unstable tandem repeat loci. This investigation will allow to select the most relevant strains for testing these hypotheses via whole genome sequencing and to subsequently adjust the genotyping scheme to the Kazakhstan epidemiological situation.</p>