Table_1_The Different Brain Mechanisms of Object and Spatial Working Memory: Voxel-Based Morphometry and Resting-State Functional Connectivity.DOC Zhiting Ren Yao Zhang Hong He Qiuyang Feng Taiyong Bi Jiang Qiu 10.3389/fnhum.2019.00248.s001 https://frontiersin.figshare.com/articles/dataset/Table_1_The_Different_Brain_Mechanisms_of_Object_and_Spatial_Working_Memory_Voxel-Based_Morphometry_and_Resting-State_Functional_Connectivity_DOC/8965979 <p>In working memory (WM), the ability to concurrently integrate different types of information and to maintain or manipulate them promotes the flow of ongoing tasks. WM is a key component of normal human cognition. In this study, we applied a combined voxel-based morphometry (VBM) and resting-state functional connectivity (rsFC) analysis to investigate the relationship between the ability of object and spatial working memory (WM), and regional gray matter density (GMD), as well as intrinsic functional connectivity. The VBM analysis showed a positive correlation between the individual difference of object WM and GMD in the right middle occipital gyrus (MOG) and the left superior temporal gyrus (STG), which are responsible for coding object information and processing the shape of an object. The individual difference of the spatial WM was positively related to GMD in the right middle frontal gyrus (MFG) located in the dorsolateral prefrontal cortex (dlPFC), which confirmed that it is an important region for memory stores and maintains WM spatial representations. Further functional connectivity analysis revealed that the individual difference of object WM was significantly correlated with the rsFC of right intraparietal sulcus (IPS) – left postcentral gyrus (PostCG)/right precentral gyrus (PreCG)/left Supplementary Motor Area (SMA). While the capacity of spatial WM was significantly associated with the FC strength of the left dlPFC – left precuneus, right dlPFC – right MFG, and the left superior frontal sulcus (SFS) – left SMA/ right inferior parietal lobe (IPL). Our findings suggest that object WM is associated with the structure and functional organization of the brain regions involved in the ventral pathway (occipital – temporal regions) and the capacity of spatial WM is related to the dorsal pathway (frontal – parietal regions).</p> 2019-07-19 13:34:22 visual working memory structure resting-state functional connectivity object working memory spatial working memory