10.3389/fimmu.2019.01688.s006
Bin Wan
Bin
Wan
Emilie Goguet
Emilie
Goguet
Marc Ravallec
Marc
Ravallec
Olivier Pierre
Olivier
Pierre
Séverine Lemauf
Séverine
Lemauf
Anne-Nathalie Volkoff
Anne-Nathalie
Volkoff
Jean-Luc Gatti
Jean-Luc
Gatti
Marylène Poirié
Marylène
Poirié
Data_Sheet_6_Venom Atypical Extracellular Vesicles as Interspecies Vehicles of Virulence Factors Involved in Host Specificity: The Case of a Drosophila Parasitoid Wasp.pdf
Frontiers
2019
Drosophila
immunity
parasitoid wasp
Leptopilina
venosomes
lamellocyte
virulence
2019-07-17 14:27:15
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_6_Venom_Atypical_Extracellular_Vesicles_as_Interspecies_Vehicles_of_Virulence_Factors_Involved_in_Host_Specificity_The_Case_of_a_Drosophila_Parasitoid_Wasp_pdf/8944745
<p>Endoparasitoid wasps, which lay eggs inside the bodies of other insects, use various strategies to protect their offspring from the host immune response. The hymenopteran species of the genus Leptopilina, parasites of Drosophila, rely on the injection of a venom which contains proteins and peculiar vesicles (hereafter venosomes). We show here that the injection of purified L. boulardi venosomes is sufficient to impair the function of the Drosophila melanogaster lamellocytes, a hemocyte type specialized in the defense against wasp eggs, and thus the parasitic success of the wasp. These venosomes seem to have a unique extracellular biogenesis in the wasp venom apparatus where they acquire specific secreted proteins/virulence factors and act as a transport system to deliver these compounds into host lamellocytes. The level of venosomes entry into lamellocytes of different Drosophila species was correlated with the rate of parasitism success of the wasp, suggesting that this venosome-cell interaction may represent a new evolutionary level of host-parasitoid specificity.</p>