%0 Generic %A Shao, Ning %A Wan, Fangning %A Abudurexiti, Mierxiati %A Wang, Jun %A Zhu, Yao %A Ye, Dingwei %D 2019 %T Data_Sheet_1_Causes of Death and Conditional Survival of Renal Cell Carcinoma.docx %U https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Causes_of_Death_and_Conditional_Survival_of_Renal_Cell_Carcinoma_docx/8870189 %R 10.3389/fonc.2019.00591.s001 %2 https://frontiersin.figshare.com/ndownloader/files/16261982 %K conditional survival %K renal cell carcinoma %K causes of death %K follow-up %K high-risk %X

Background: As conditional survival could provide more relevant prognostic information at each follow-up time, the present study aimed to assess conditional overall survival (COS) based on two cohorts and assess the risks of death due to renal cell carcinoma (RCC) vs. other causes.

Methods: The Fudan University Shanghai Cancer Center (FUSCC) and Surveillance, Epidemiology, and End Results (SEER) database were used as the source of data for our analysis. COS and cancer-specific survival were evaluated using the Kaplan–Meier method.

Results: A total of 90,927 patients (SEER cohort = 88,807, FUSCC cohort = 2,120) were enrolled. Our results suggest that hazards of other causes-related death were always higher than that of cancer-specific death in low-risk RCC patients, but lower in metastatic RCC patients. It exceeded that of cancer-specific death by 8 years in high-risk RCC patients. Only in metastatic RCC patients, the COS improved markedly with survivorship increasing. After surviving 1, 2, 3, 4, and 5 years, the 5 years COS increased by +10, +18, +23, +29, and 35% (the observed 5 years OS: 12%), respectively.

Conclusions: COS can better help patients with metastatic RCC rather than other RCC patients. Additionally, COS brings optimism for metastatic RCC patients with expected poorer prognosis psychologically.

%I Frontiers