10.3389/fcell.2019.00124.s001
Lana Vasung
Lana
Vasung
Arthur Rezayev
Arthur
Rezayev
Hyuk Jin Yun
Hyuk Jin
Yun
Jae W. Song
Jae W.
Song
Andre van der Kouwe
Andre
van der Kouwe
Natalie Stewart
Natalie
Stewart
Arthi Palani
Arthi
Palani
Tadashi Shiohama
Tadashi
Shiohama
Francois Chouinard-Decorte
Francois
Chouinard-Decorte
Jacob Levman
Jacob
Levman
Emi Takahashi
Emi
Takahashi
Data_Sheet_1_Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly.docx
Frontiers
2019
lissencephaly
gyrification
LIS1
DCX mutation
MRI
DTI
2019-07-11 15:09:25
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Structural_and_Diffusion_MRI_Analyses_With_Histological_Observations_in_Patients_With_Lissencephaly_docx/8859188
<p>The development of cortical convolutions, gyri and sulci, is a complex process that takes place during prenatal development. Lissencephaly, a rare genetic condition characterized by the lack of cortical convolutions, offers a model to look into biological processes that lead to the development of convolutions. Retrospective, qualitative, and quantitative analyses of structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were performed in patients with lissencephaly (N = 10) and age-/sex-matched controls (N = 10). In order to identify microstructural correlates of structural MRI and DTI findings, postmortem brains of patients with lissencephaly (N = 4) and age-matched controls (N = 4) were also examined with histology. Patients with lissencephaly had significantly smaller gyrification index and volumes of hemispheric white and gray matter, compared to the age-/sex-matched control group. However, there was no significant difference between groups in the subcortical gray matter volumes. Although the majority of patients with lissencephaly had a preserved normal-like appearance of major fissures and primary sulci, the spatial distribution of agyric cortical regions was different in patients with lissencephaly-1 (LIS1) and doublecortin (DCX) mutations. Lastly, in patients with lissencephaly, the spatiotemporal distribution of projection pathways was preserved while short- to medium-range cortico-cortical pathways were absent or fewer in number. Our results indicate that in the patients with lissencephaly cortical system is affected more than the subcortical one.</p>