Data_Sheet_1_Alkylative Ring-Opening of Bicyclic Aziridinium Ion and Its Application for Alkaloid Synthesis.doc
Nagendra Nath Yadav
Young-Gun Lee
Nikhil Srivastava
Hyun-Joon Ha
10.3389/fchem.2019.00460.s001
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Alkylative_Ring-Opening_of_Bicyclic_Aziridinium_Ion_and_Its_Application_for_Alkaloid_Synthesis_doc/8332409
<p>Alkylative ring-opening of bicyclic aziridinium ion generated from 4-hydroxybutylaziridine with organocopper reagent was achieved successfully to afford 2-alkylsubstituted piperidine in high or moderate yield. This method allowed carbon-carbon bond formation of “non-activated” aziridine via aziridinium ion ring-opening in regio- and stereo-selective manner for the first time. This newly developed reaction was applied for an efficient synthesis of alkaloid with the representative example of conine and epiquinamide.</p>
2019-06-27 08:58:41
aziridine
bicyclic aziridinium ions
alkylation
ring-expansion
alkaloid synthesis