Image_1_Single-Trial EEG-fMRI Reveals the Generation Process of the Mismatch Negativity.JPEG Qiang Li Guangyuan Liu Guangjie Yuan Gaoyuan Wang Zonghui Wu Xingcong Zhao 10.3389/fnhum.2019.00168.s001 https://frontiersin.figshare.com/articles/figure/Image_1_Single-Trial_EEG-fMRI_Reveals_the_Generation_Process_of_the_Mismatch_Negativity_JPEG/8188913 <p>Although research on the mismatch negativity (MMN) has been ongoing for 40 years, the generation process of the MMN remains largely unknown. In this study, we used a single-trial electro-encephalography (EEG)-functional magnetic resonance imaging (fMRI) coupling method which can analyze neural activity with both high temporal and high spatial resolution and thus assess the generation process of the MMN. We elicited the MMN with an auditory oddball paradigm while recording simultaneous EEG and fMRI. We divided the MMN into five equal-durational phases. Utilizing the single-trial variability of the MMN, we analyzed the neural generators of the five phases, thereby determining the spatiotemporal generation process of the MMN. We found two distinct bottom-up prediction error propagations: first from the auditory cortex to the motor areas and then from the auditory cortex to the inferior frontal gyrus (IFG). Our results support the regularity-violation hypothesis of MMN generation.</p> 2019-05-28 04:14:16 EEG FMRI MMN generation process single-trial EEG