%0 Generic %A Zhang, Chao %A Wang, Guanzhen %A Han, Hai-Hao %A Hu, Xi-Le %A Field, Robert A. %A Chen, Guo-Rong %A Li, Jia %A Ye, Bing %A He, Xiao-Peng %A Zang, Yi %D 2019 %T Data_Sheet_1_Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging.docx %U https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Self-Assembled_Thin-Layer_Glycomaterials_With_a_Proper_Shell_Thickness_for_Targeted_and_Activatable_Cell_Imaging_docx/8094017 %R 10.3389/fchem.2019.00294.s001 %2 https://frontiersin.figshare.com/ndownloader/files/15102749 %K fluorescence %K precision %K imaging %K activatable %K receptor %X

The construction of targeted and activatable materials can largely improve the precision of disease diagnosis and therapy. However, the currently developed systems either target a transmembrane antigen or are activatable to release imaging and/or therapeutic reagents intracellularly. Here, we develop a simple thin-layer glycomaterial through the self-assembly between fluorescent glycoprobes, in which the carbohydrate-targeting reagent and the fluorophore are linked to each other by polyethylene glycol with a suitable chain length, and thin-layer manganese dioxide. The fluorogenic material developed is both capable of targeting a transmembrane glycoprotein receptor and fluorescently activatable by intracellular biothiols. The shell thickness of the material was determined to be important for achieving the biothiol-induced activation of fluorescence. This research might provide insight into the development of precision-enhanced self-assembled materials for disease theranostics.

%I Frontiers