10.3389/fphar.2019.00445.s001 Ruili Huang Ruili Huang Ivan Grishagin Ivan Grishagin Yuhong Wang Yuhong Wang Tongan Zhao Tongan Zhao Jon Greene Jon Greene John C. Obenauer John C. Obenauer Deborah Ngan Deborah Ngan Dac-Trung Nguyen Dac-Trung Nguyen Rajarshi Guha Rajarshi Guha Ajit Jadhav Ajit Jadhav Noel Southall Noel Southall Anton Simeonov Anton Simeonov Christopher P. Austin Christopher P. Austin Data_Sheet_1_The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics.pdf Frontiers 2019 BioPlanet pathway systems biology chemical genomics in vitro assay 2019-04-26 04:05:41 Dataset https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_The_NCATS_BioPlanet_An_Integrated_Platform_for_Exploring_the_Universe_of_Cellular_Signaling_Pathways_for_Toxicology_Systems_Biology_and_Chemical_Genomics_pdf/8045009 <p>Chemical genomics aims to comprehensively define, and ultimately predict, the effects of small molecule compounds on biological systems. Chemical activity profiling approaches must consider chemical effects on all pathways operative in mammalian cells. To enable a strategic and maximally efficient chemical profiling of pathway space, we have created the NCATS BioPlanet, a comprehensive integrated pathway resource that incorporates the universe of 1,658 human pathways sourced from publicly available, manually curated sources, which have been subjected to thorough redundancy and consistency cross-evaluation. BioPlanet supports interactive browsing, retrieval, and analysis of pathways, exploration of pathway connections, and pathway search by gene targets, category, and availability of corresponding bioactivity assay, as well as visualization of pathways on a 3-dimensional globe, in which the distance between any two pathways is proportional to their degree of gene component overlap. Using this resource, we propose a strategy to identify a minimal set of 362 biological assays that can interrogate the universe of human pathways. The NCATS BioPlanet is a public resource, which will be continually expanded and updated, for systems biology, toxicology, and chemical genomics, available at http://tripod.nih.gov/bioplanet/.</p>