10.3389/fphar.2019.00445.s001
Ruili Huang
Ruili
Huang
Ivan Grishagin
Ivan
Grishagin
Yuhong Wang
Yuhong
Wang
Tongan Zhao
Tongan
Zhao
Jon Greene
Jon
Greene
John C. Obenauer
John C.
Obenauer
Deborah Ngan
Deborah
Ngan
Dac-Trung Nguyen
Dac-Trung
Nguyen
Rajarshi Guha
Rajarshi
Guha
Ajit Jadhav
Ajit
Jadhav
Noel Southall
Noel
Southall
Anton Simeonov
Anton
Simeonov
Christopher P. Austin
Christopher P.
Austin
Data_Sheet_1_The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics.pdf
Frontiers
2019
BioPlanet
pathway
systems biology
chemical genomics
in vitro assay
2019-04-26 04:05:41
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_The_NCATS_BioPlanet_An_Integrated_Platform_for_Exploring_the_Universe_of_Cellular_Signaling_Pathways_for_Toxicology_Systems_Biology_and_Chemical_Genomics_pdf/8045009
<p>Chemical genomics aims to comprehensively define, and ultimately predict, the effects of small molecule compounds on biological systems. Chemical activity profiling approaches must consider chemical effects on all pathways operative in mammalian cells. To enable a strategic and maximally efficient chemical profiling of pathway space, we have created the NCATS BioPlanet, a comprehensive integrated pathway resource that incorporates the universe of 1,658 human pathways sourced from publicly available, manually curated sources, which have been subjected to thorough redundancy and consistency cross-evaluation. BioPlanet supports interactive browsing, retrieval, and analysis of pathways, exploration of pathway connections, and pathway search by gene targets, category, and availability of corresponding bioactivity assay, as well as visualization of pathways on a 3-dimensional globe, in which the distance between any two pathways is proportional to their degree of gene component overlap. Using this resource, we propose a strategy to identify a minimal set of 362 biological assays that can interrogate the universe of human pathways. The NCATS BioPlanet is a public resource, which will be continually expanded and updated, for systems biology, toxicology, and chemical genomics, available at http://tripod.nih.gov/bioplanet/.</p>