%0 Generic %A Fu, Songzhe %A Hao, Jingwei %A Jin, Shibo %A Wu, Kui %A Wang, Yi %A Ye, Shigen %A Liu, Ying %A Li, Ruijun %D 2019 %T Data_Sheet_1_A Human Intestinal Infection Caused by a Novel Non-O1/O139 Vibrio cholerae Genotype and Its Dissemination Along the River.PDF %U https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_A_Human_Intestinal_Infection_Caused_by_a_Novel_Non-O1_O139_Vibrio_cholerae_Genotype_and_Its_Dissemination_Along_the_River_PDF/8033600 %R 10.3389/fpubh.2019.00100.s001 %2 https://frontiersin.figshare.com/ndownloader/files/14963609 %K Vibrio cholerae %K genomic surveillance %K movement of water %K mollusc %K core genomic typing %X

Non-O1/O139 Vibrio cholerae is increasingly reported in the clinical settings. However, intestinal infections via the consumption of non-O1/O139 V. cholerae-carrying seafood are rarely documented in China. In this study, we reported a case of mild watery diarrhea in a young male, caused by non-O1/O139 V. cholerae in the downstream of Liaohe River. Epidemiological investigation showed that this intestinal infection potentially associated with the raw consumption of mollusc. Prior to this finding, we conducted a 6-month pathogen surveillance of three locations along the Liaohe River and identified three environmental non-O1/O139 V. cholerae strains. To confirm the epidemiological links between clinical and environmental strains, high-resolution genomic typing was employed and revealed that V. cholerae isolated from human stool sample was genomically related to the one found in local mollusc and shared a common ancestor with other environmental strains obtained in the upstream sites of the Liaohe River. This fact suggests that the river is a natural reservoir for non-O1/O139 V. cholerae which poses a potential threat to the public health. In summary, our results deepened the insights on the transmission of non-pandemic V. cholerae strains and underscored the significance of genomic surveillance for drinking water along the river sites.

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