10.3389/fpubh.2019.00100.s001 Songzhe Fu Songzhe Fu Jingwei Hao Jingwei Hao Shibo Jin Shibo Jin Kui Wu Kui Wu Yi Wang Yi Wang Shigen Ye Shigen Ye Ying Liu Ying Liu Ruijun Li Ruijun Li Data_Sheet_1_A Human Intestinal Infection Caused by a Novel Non-O1/O139 Vibrio cholerae Genotype and Its Dissemination Along the River.PDF Frontiers 2019 Vibrio cholerae genomic surveillance movement of water mollusc core genomic typing 2019-04-24 05:35:17 Dataset https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_A_Human_Intestinal_Infection_Caused_by_a_Novel_Non-O1_O139_Vibrio_cholerae_Genotype_and_Its_Dissemination_Along_the_River_PDF/8033600 <p>Non-O1/O139 Vibrio cholerae is increasingly reported in the clinical settings. However, intestinal infections via the consumption of non-O1/O139 V. cholerae-carrying seafood are rarely documented in China. In this study, we reported a case of mild watery diarrhea in a young male, caused by non-O1/O139 V. cholerae in the downstream of Liaohe River. Epidemiological investigation showed that this intestinal infection potentially associated with the raw consumption of mollusc. Prior to this finding, we conducted a 6-month pathogen surveillance of three locations along the Liaohe River and identified three environmental non-O1/O139 V. cholerae strains. To confirm the epidemiological links between clinical and environmental strains, high-resolution genomic typing was employed and revealed that V. cholerae isolated from human stool sample was genomically related to the one found in local mollusc and shared a common ancestor with other environmental strains obtained in the upstream sites of the Liaohe River. This fact suggests that the river is a natural reservoir for non-O1/O139 V. cholerae which poses a potential threat to the public health. In summary, our results deepened the insights on the transmission of non-pandemic V. cholerae strains and underscored the significance of genomic surveillance for drinking water along the river sites.</p>