10.3389/fphys.2019.00462.s001
Sara Artigas-Jerónimo
Sara
Artigas-Jerónimo
Agustín Estrada-Peña
Agustín
Estrada-Peña
Alejandro Cabezas-Cruz
Alejandro
Cabezas-Cruz
Pilar Alberdi
Pilar
Alberdi
Margarita Villar
Margarita
Villar
José de la Fuente
José
de la Fuente
Data_Sheet_1_Modeling Modulation of the Tick Regulome in Response to Anaplasma phagocytophilum for the Identification of New Control Targets.PDF
Frontiers
2019
regulome
transcription
tick
Ixodes scapularis
Anaplasma phagocytophilum
ISE6 cells
vaccine
2019-04-18 04:16:15
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Modeling_Modulation_of_the_Tick_Regulome_in_Response_to_Anaplasma_phagocytophilum_for_the_Identification_of_New_Control_Targets_PDF/8010023
<p>Ticks act as vectors of pathogens affecting human and animal health worldwide, and recent research has focused on the characterization of tick-pathogen interactions using omics technologies to identify new targets for developing novel control interventions. The regulome (transcription factors-target genes interactions) plays a critical role in cell response to pathogen infection. Therefore, the application of regulomics to tick-pathogen interactions would advance our understanding of these molecular interactions and contribute to the identification of novel control targets for the prevention and control of tick infestations and tick-borne diseases. However, limited information is available on the role of tick regulome in response to pathogen infection. In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-pathogen interactions, and the identification of new antigens for the control of tick infestations and pathogen infection/transmission.</p>