10.3389/fphar.2019.00352.s002
Carmela Belardo
Carmela
Belardo
Monica Iannotta
Monica
Iannotta
Serena Boccella
Serena
Boccella
Rosamaria Cristina Rubino
Rosamaria Cristina
Rubino
Flavia Ricciardi
Flavia
Ricciardi
Rosmara Infantino
Rosmara
Infantino
Gorizio Pieretti
Gorizio
Pieretti
Luigi Stella
Luigi
Stella
Salvatore Paino
Salvatore
Paino
Ida Marabese
Ida
Marabese
Rosa Maisto
Rosa
Maisto
Livio Luongo
Livio
Luongo
Sabatino Maione
Sabatino
Maione
Francesca Guida
Francesca
Guida
Image_2_Oral Cannabidiol Prevents Allodynia and Neurological Dysfunctions in a Mouse Model of Mild Traumatic Brain Injury.TIF
Frontiers
2019
cannabidiol
traumatic brain injury
pain
behavior
microdialysis
2019-04-16 04:16:39
Figure
https://frontiersin.figshare.com/articles/figure/Image_2_Oral_Cannabidiol_Prevents_Allodynia_and_Neurological_Dysfunctions_in_a_Mouse_Model_of_Mild_Traumatic_Brain_Injury_TIF/7996724
<p>Neurological dysfunctions are the most impactful and persistent consequences of traumatic brain injury (TBI). Indeed, previous reports suggest that an association between TBI and chronic pain syndromes, as well anxio-depressive behaviors, tends to be more common in patients with mild forms of TBI. At present, no effective treatment options are available for these symptoms. In the present study, we used a weight drop mild TBI mouse model to investigate the effect of a commercially available 10% Cannabidiol (CBD) oil on both the sensorial and neuropsychiatric dysfunctions associated with mild TBI through behavioral and biomolecular approaches. TBI mice developed chronic pain associated with anxious and aggressive behavior, followed by a late depressive-like behavior and impaired social interaction. Such behaviors were related with specific changes in neurotransmitters release at cortical levels. CBD oral treatment restored the behavioral alterations and partially normalized the cortical biochemical changes. In conclusion, our data show some of the brain modifications probably responsible for the behavioral phenotype associated with TBI and suggest the CBD as a pharmacological tool to improve neurological dysfunctions caused by the trauma.</p>