10.3389/fmicb.2019.00712.s006 Guangwen Luo Guangwen Luo Bailiang Li Bailiang Li Cailu Yang Cailu Yang Yutang Wang Yutang Wang Xin Bian Xin Bian Wan Li Wan Li Fei Liu Fei Liu Guicheng Huo Guicheng Huo Table_2_Major Traditional Probiotics: Comparative Genomic Analyses and Roles in Gut Microbiome of Eight Cohorts.XLSX Frontiers 2019 major traditional probiotics species comparative genomic analyses complementarity potentials roles in gut microbiome cohorts 2019-04-09 05:30:42 Dataset https://frontiersin.figshare.com/articles/dataset/Table_2_Major_Traditional_Probiotics_Comparative_Genomic_Analyses_and_Roles_in_Gut_Microbiome_of_Eight_Cohorts_XLSX/7969187 <p>Modulating gut microbiota to promote host health is well recognized. Therefore, people consume dietary products containing traditional probiotics in wishing to improve their health, and they need more research-based advices on how to select products with suitable probiotic species. Probiotic designers are sometimes confused about how to design precision products for different consumers by taking advantages of different probiotic species’ strengths. Additionally, large-scale analyses on traditional probiotic complementarity potentials and their roles in gut microbiome related to common diseases are not well understood. Here, we comprehensively analyzed 444 genomes of major traditional probiotic (sub) species (MTPS, n = 15) by combining one newly sequenced genome with all of the public NCBI-available MTPS-related genomes. The public human fecal metagenomic data (n = 1,815) of eight cohorts were used to evaluate the roles of MTPS, compared to other main gut bacteria, in disease association by examining the species enrichment direction in disease group or the control group. Our work provided a comprehensive genetic landscape and complementarity relations for MTPS and shed light on personalized probiotic supplements for consumers with different health status and the necessity that researchers and manufactures could explore novel probiotics as well as traditional ones.</p>