10.3389/fnins.2019.00302.s004
Ulises Gómez-Pinedo
Ulises
Gómez-Pinedo
Lucía Galán
Lucía
Galán
Jordi A. Matías-Guiu
Jordi A.
Matías-Guiu
Vanesa Pytel
Vanesa
Pytel
Teresa Moreno
Teresa
Moreno
Antonio Guerrero-Sola
Antonio
Guerrero-Sola
Jorge Matías-Guiu
Jorge
Matías-Guiu
Image_2_Notch Signalling in the Hippocampus of Patients With Motor Neuron Disease.TIF
Frontiers
2019
ALS
Notch
NICD
APP
ADAM10
ADAM17
BACE1
hippocampal neurogenesis
2019-04-05 11:09:51
Figure
https://frontiersin.figshare.com/articles/figure/Image_2_Notch_Signalling_in_the_Hippocampus_of_Patients_With_Motor_Neuron_Disease_TIF/7957907
Introduction<p>The Notch signalling pathway regulates neuronal survival. It has some similarities with the APP signalling pathway, and competes with the latter for α- and γ-secretase proteolytic complexes. The objective of this study was to study the Notch signalling pathway in the hippocampi of patients with motor neuron disease.</p>Methods<p>We studied biological material from the autopsies of 12 patients with motor neuron disease and 4 controls. We analysed the molecular markers of the Notch and APP signalling pathways, TDP43, tau, and markers of neurogenesis.</p>Results and Conclusion<p>Low NICD expression suggests Notch signalling pathway inactivation in neurons. Inactivation of the pathway despite increased Notch1 expression is associated with a lack of α-secretase expression. We observed increased β-secretase expression associated with activation of the amyloid cascade of APP, leading to increases in amyloid-β and AICD peptides and decreased levels of Fe65. Inactivation of the Notch signalling pathway is an important factor in decreased neurogenic response in the hippocampi of patients with amyotrophic lateral sclerosis.</p>