10.3389/fncel.2019.00133.s001
Dongxue Li
Dongxue
Li
Dongqing Jing
Dongqing
Jing
Ziyang Liu
Ziyang
Liu
Ying Chen
Ying
Chen
Fang Huang
Fang
Huang
Thomas Behnisch
Thomas
Behnisch
Image_1_Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice.TIFF
Frontiers
2019
klotho
object recognition and location memory
hippocampal formation/hippocampus
passive avoidance memory
anti-aging
nesting behavior
2019-04-02 04:08:48
Figure
https://frontiersin.figshare.com/articles/figure/Image_1_Enhanced_Expression_of_Secreted_-Klotho_in_the_Hippocampus_Alters_Nesting_Behavior_and_Memory_Formation_in_Mice_TIFF/7935227
<p>The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can be expressed and secreted. Inactivation of α-Klotho leads to a phenotype that resembles accelerated aging, as the expression level of the α-Klotho protein in the hippocampal formation of mice decreases with age. Here, we show that intrahippocampal viral expression of secreted human α-Klotho alters social behavior and memory formation. Interestingly, overexpression of secreted human α-Klotho in the CA1 changed the nest-building behavior and improved object recognition, object location and passive avoidance memory. Moreover, α-Klotho overexpression increased hippocampal synaptic transmission in response to standardized stimulation strengths, altered paired-pulse facilitation of synaptic transmission, and enhanced activity-dependent synaptic plasticity. These results indicate that memory formation benefits from an augmented level of secreted α-Klotho.</p>