Data_Sheet_1_Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds.pdf Mariarita Perri Francesca Aiello Erika Cione Gabriele Carullo Luisa Amendola Sarah Mazzotta Maria Cristina Caroleo 10.3389/fmolb.2019.00012.s001 https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Investigation_of_TNBC_in_vitro_Antiproliferative_Effects_of_Versatile_Pirrolo_1_2-a_quinoxaline_Compounds_pdf/7829447 <p>The triple-negative breast cancer (TNBC) is characterized by a more aggressive nature and poorer prognosis, nowadays none pharmaceutical approach is still available. For this reason, the research of new active compounds and attractive targets represents an interesting field. In this context MDA- MB-231 cell line was selected to evaluate the antiproliferative effects of new [1,2-a]-pyrroloquinoxaline derivatives. The MTT assay revealed that the amine forms of synthesized molecules were more active compared to iminic ones at 72 h of incubation. The antiproliferative effect of the most promising compounds highlighted the formation of autophagic vacuoles.</p> 2019-03-12 04:50:53 pyrroloquinoxalines triple-negative breast cancer autophagy antiproliferative activity one-pot reaction