10.3389/fmolb.2019.00012.s001
Mariarita Perri
Mariarita
Perri
Francesca Aiello
Francesca
Aiello
Erika Cione
Erika
Cione
Gabriele Carullo
Gabriele
Carullo
Luisa Amendola
Luisa
Amendola
Sarah Mazzotta
Sarah
Mazzotta
Maria Cristina Caroleo
Maria Cristina
Caroleo
Data_Sheet_1_Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds.pdf
Frontiers
2019
pyrroloquinoxalines
triple-negative breast cancer
autophagy
antiproliferative activity
one-pot reaction
2019-03-12 04:50:53
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Investigation_of_TNBC_in_vitro_Antiproliferative_Effects_of_Versatile_Pirrolo_1_2-a_quinoxaline_Compounds_pdf/7829447
<p>The triple-negative breast cancer (TNBC) is characterized by a more aggressive nature and poorer prognosis, nowadays none pharmaceutical approach is still available. For this reason, the research of new active compounds and attractive targets represents an interesting field. In this context MDA- MB-231 cell line was selected to evaluate the antiproliferative effects of new [1,2-a]-pyrroloquinoxaline derivatives. The MTT assay revealed that the amine forms of synthesized molecules were more active compared to iminic ones at 72 h of incubation. The antiproliferative effect of the most promising compounds highlighted the formation of autophagic vacuoles.</p>