10.3389/fmolb.2019.00012.s001 Mariarita Perri Mariarita Perri Francesca Aiello Francesca Aiello Erika Cione Erika Cione Gabriele Carullo Gabriele Carullo Luisa Amendola Luisa Amendola Sarah Mazzotta Sarah Mazzotta Maria Cristina Caroleo Maria Cristina Caroleo Data_Sheet_1_Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds.pdf Frontiers 2019 pyrroloquinoxalines triple-negative breast cancer autophagy antiproliferative activity one-pot reaction 2019-03-12 04:50:53 Dataset https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Investigation_of_TNBC_in_vitro_Antiproliferative_Effects_of_Versatile_Pirrolo_1_2-a_quinoxaline_Compounds_pdf/7829447 <p>The triple-negative breast cancer (TNBC) is characterized by a more aggressive nature and poorer prognosis, nowadays none pharmaceutical approach is still available. For this reason, the research of new active compounds and attractive targets represents an interesting field. In this context MDA- MB-231 cell line was selected to evaluate the antiproliferative effects of new [1,2-a]-pyrroloquinoxaline derivatives. The MTT assay revealed that the amine forms of synthesized molecules were more active compared to iminic ones at 72 h of incubation. The antiproliferative effect of the most promising compounds highlighted the formation of autophagic vacuoles.</p>