10.3389/fphys.2019.00212.s005 Guanghui Zhu Guanghui Zhu Shihao Li Shihao Li Jun Wu Jun Wu Fuhua Li Fuhua Li Xing-Ming Zhao Xing-Ming Zhao Data_Sheet_4_Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp.ZIP Frontiers 2019 antivirus response co-expression network gene module STAT dsRNA white spot syndrome virus shrimp 2019-03-11 04:25:51 Dataset https://frontiersin.figshare.com/articles/dataset/Data_Sheet_4_Identification_of_Functional_Gene_Modules_Associated_With_STAT-Mediated_Antiviral_Responses_to_White_Spot_Syndrome_Virus_in_Shrimp_ZIP/7824488 <p>White spot syndrome virus (WSSV) is one of the major threats to shrimp aquaculture. It has been found that the signal transducer and activator of transcription (STAT) protein plays an important role in the antiviral immunity of shrimp with a WSSV infection. However, the mechanism that underlies the STAT-mediated antiviral responses in shrimp, against WSSV infection, remains unclear. In this work, based on the gene expression profiles of shrimp with an injection of WSSV and STAT double strand RNA (dsRNA), we constructed a gene co-expression network for shrimp and identified the gene modules that are possibly responsible for STAT-mediated antiviral responses. These gene modules are found enriched in the regulation of the viral process, JAK-STAT cascade and the regulation of immune effector process pathways. The gene modules identified here provide insights into the molecular mechanism that underlies the STAT-mediated antiviral response of shrimp, against WSSV.</p>