10.3389/fphys.2019.00133.s007
Paola Cusumano
Paola
Cusumano
Milena Damulewicz
Milena
Damulewicz
Elena Carbognin
Elena
Carbognin
Laura Caccin
Laura
Caccin
Antonietta Puricella
Antonietta
Puricella
Valeria Specchia
Valeria
Specchia
Maria Pia Bozzetti
Maria
Pia Bozzetti
Rodolfo Costa
Rodolfo
Costa
Gabriella M. Mazzotta
Gabriella
M. Mazzotta
Image_6_The RNA Helicase BELLE Is Involved in Circadian Rhythmicity and in Transposons Regulation in Drosophila melanogaster.TIF
Frontiers
2019
RNA helicase BELLE
Drosophila
post-transcriptional control
circadian clock
piRNA-mediated transposons regulation
2019-02-20 16:12:50
Figure
https://frontiersin.figshare.com/articles/figure/Image_6_The_RNA_Helicase_BELLE_Is_Involved_in_Circadian_Rhythmicity_and_in_Transposons_Regulation_in_Drosophila_melanogaster_TIF/7746488
<p>Circadian clocks control and synchronize biological rhythms of several behavioral and physiological phenomena in most, if not all, organisms. Rhythm generation relies on molecular auto-regulatory oscillations of interlocked transcriptional-translational feedback loops. Rhythmic clock-gene expression is at the base of rhythmic protein accumulation, though post-transcriptional and post-translational mechanisms have evolved to adjust and consolidate the proper pace of the clock. In Drosophila, BELLE, a conserved DEAD-box RNA helicase playing important roles in reproductive capacity, is involved in the small RNA-mediated regulation associated to the piRNA pathway. Here, we report that BELLE is implicated in the circadian rhythmicity and in the regulation of endogenous transposable elements (TEs) in both nervous system and gonads. We suggest that BELLE acts as important element in the piRNA-mediated regulation of the TEs and raise the hypothesis that this specific regulation could represent another level of post-transcriptional control adopted by the clock to ensure the proper rhythmicity.</p>