10.3389/fnhum.2018.00539.s001
Fan Yang
Fan
Yang
Linlin Fan
Linlin
Fan
Tianyi Zhai
Tianyi
Zhai
Ying Lin
Ying
Lin
Yuyin Wang
Yuyin
Wang
Junji Ma
Junji
Ma
Mei Liao
Mei
Liao
Yan Zhang
Yan
Zhang
Lingjiang Li
Lingjiang
Li
Linyan Su
Linyan
Su
Zhengjia Dai
Zhengjia
Dai
Data_Sheet_1_Decreased Intrinsic Functional Connectivity in First-Episode, Drug-Naive Adolescents With Generalized Anxiety Disorder.docx
Frontiers
2019
generalized anxiety disorder
connectome
functional connectivity
graph theory
supramarginal gyrus
superior parietal gyrus
2019-01-11 09:07:26
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Decreased_Intrinsic_Functional_Connectivity_in_First-Episode_Drug-Naive_Adolescents_With_Generalized_Anxiety_Disorder_docx/7577603
<p>Generalized anxiety disorder (GAD) is characterized by excessive and uncontrollable worry about everyday life. Prior neuroimaging studies have demonstrated that GAD is associated with disruptions in specific brain regions; however, little is known about the global functional connectivity maps in adolescents with GAD. Here, first-episode, medication-naive, adolescent GAD patients (N = 36) and healthy controls (N = 28) (HCs) underwent resting-state functional MRI (R-fMRI) and completed a package of questionnaires to assess clinical symptoms. Functional connectivity strength and seed-based functional connectivity were employed to investigate the functional connectivity architecture. GAD patients showed reduced functional connectivity strength in right supramarginal gyrus (SMG) and right superior parietal gyrus (SPG) compared with HCs. Further seed-based functional connectivity analysis revealed that GAD patients displayed decreased functional connectivity between right SMG and left fusiform gyrus, inferior temporal gyrus, parahippocampal gyrus, bilateral precuneus and cuneus, and between right SPG and bilateral supplementary motor area and middle cingulate gyrus, as well as between the SMG-based network and the SPG-based network. Moreover, the disrupted intra-network connectivity (i.e., the SMG-based network and the SPG-based network) and inter-network connectivity between the SMG-based network and the SPG-based network accounted for 25.5% variance of the State and Trait Anxiety Inventory (STAI) and 39.5% variance of the trait subscale of STAI. Our findings highlight the abnormal functional architecture in the SMG-based network and the SPG-based network in GAD, providing novel insights into the pathological mechanisms of this disorder.</p>