10.3389/fncel.2018.00500.s001
Ruanna Wang
Ruanna
Wang
Jiahui Tan
Jiahui
Tan
Junxiu Guo
Junxiu
Guo
Yuhan Zheng
Yuhan
Zheng
Qing Han
Qing
Han
Kwok-Fai So
Kwok-Fai
So
Jiandong Yu
Jiandong
Yu
Li Zhang
Li
Zhang
Data_Sheet_1_Aberrant Development and Synaptic Transmission of Cerebellar Cortex in a VPA Induced Mouse Autism Model.PDF
Frontiers
2018
autism
cerebellum
environmental exposure
motor learning
postnatal development
2018-12-21 04:13:18
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Aberrant_Development_and_Synaptic_Transmission_of_Cerebellar_Cortex_in_a_VPA_Induced_Mouse_Autism_Model_PDF/7496858
<p>Autistic spectral disorder (ASD) is a prevalent neurodevelopmental disease that affects multiple brain regions. Both clinical and animal studies have revealed the possible involvement of the cerebellum in ASD pathology. In this study, we generated a rodent ASD model through a single prenatal administration of valproic acid (VPA) into pregnant mice, followed by cerebellar morphological and functional studies of the offspring. Behavioral studies showed that VPA exposure led to retardation of critical motor reflexes in juveniles and impaired learning in a tone-conditioned complex motor task in adults. These behavioral phenotypes were associated with premature migration and excess apoptosis of the granular cell (GC) precursor in the cerebellar cortex during the early postnatal period, and the decreased cell density and impaired dendritic arborization of the Purkinje neurons. On acute cerebellar slices, suppressed synaptic transmission of the Purkinje cells were reported in the VPA-treated mice. In summary, converging evidence from anatomical, electrophysiological and behavioral abnormalities in the VPA-treated mice suggest cerebellar pathology in ASD and indicate the potential values of motor dysfunction in the early diagnosis of ASD.</p>