10.3389/fncir.2018.00109.s001 Ayako Hayashi Ayako Hayashi Takashi Yoshida Takashi Yoshida Kenichi Ohki Kenichi Ohki Data_Sheet_1_Cell Type Specific Representation of Vibro-tactile Stimuli in the Mouse Primary Somatosensory Cortex.docx Frontiers 2018 somatosensory cortex vibro-tactile sensation inhibitory cells functional subnetworks two-photon imaging 2018-12-20 14:41:14 Dataset https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Cell_Type_Specific_Representation_of_Vibro-tactile_Stimuli_in_the_Mouse_Primary_Somatosensory_Cortex_docx/7491980 <p>Although the processing of whisker deflections in the barrel area of the rodent primary somatosensory cortex (S1) has been studied extensively, how cutaneous vibro-tactile stimuli are processed in the rodent S1 outside the barrel area has not been fully examined. Particularly, the cell-type specific representation of multiple vibration frequencies in genetically identified inhibitory cells in the S1 has not been examined. Using two-photon calcium imaging, we examined the responses to vibration stimuli of excitatory and inhibitory neurons in the S1 hind limb area of male and female mice. The excitatory cells showed relatively sharp selectivity to vibration stimuli, whereas the inhibitory cells exhibited less selectivity. The excitatory and inhibitory cells with different preferred stimuli were intermingled in a “salt and pepper” manner. Furthermore, the noise correlation tended to be especially strong in excitatory-inhibitory and inhibitory-inhibitory cell pairs that have similar stimulus selectivity. These results suggest that excitatory cells tend to represent specific stimulus information and work together with similarly tuned inhibitory cells as a functionally connected network.</p>