10.3389/fnmol.2018.00451.s001
Rui Wang
Rui
Wang
Junhua Yuan
Junhua
Yuan
Caishun Zhang
Caishun
Zhang
Liuxin Wang
Liuxin
Wang
Yuan Liu
Yuan
Liu
Limin Song
Limin
Song
Weizhen Zhong
Weizhen
Zhong
Xi Chen
Xi
Chen
Jing Dong
Jing
Dong
Image_1_Neuropeptide Y-Positive Neurons in the Dorsomedial Hypothalamus Are Involved in the Anorexic Effect of Angptl8.TIF
Frontiers
2018
Angptl8
neuropeptide Y
appetite
dorsomedial hypothalamus
adipose tissue
2018-12-18 04:31:16
Figure
https://frontiersin.figshare.com/articles/figure/Image_1_Neuropeptide_Y-Positive_Neurons_in_the_Dorsomedial_Hypothalamus_Are_Involved_in_the_Anorexic_Effect_of_Angptl8_TIF/7476893
<p>Angiopoietin-like protein 8 (Angptl8), a recently identified member of the angiopoietin-like protein family (ANGPTLs), is a 22-kDa peptide synthesized in the liver. It participates in lipid metabolism by inhibiting lipoprotein lipase (LPL) activity, consequently increasing the triglyceride levels. Despite evidence that Angptl8 is involved in feeding control, the underlying mechanisms are unclear. Central and peripheral injections of Angptl8 significantly decreased food intake. Angptl8 was widely expressed in appetite-related nuclei, including the paraventricular nucleus (PVN), the dorsomedial hypothalamus (DMH), the ventromedial hypothalamus, and the arcuate nucleus (ARC) in the hypothalamus. Peripheral Angptl8 administration decreased c-Fos-positive neurons in the DMH. Central Angptl8 administration decreased c-Fos-positive neurons in the DMH and PVN but increased these neurons in the ARC. Angptl8 inhibited appetite via neuropeptide Y (NPY) neurons in the DMH. Furthermore, the chronic administration of Angptl8 decreased body weight gain and altered adipose tissue deposits. Nevertheless, neither peripheral nor central Angptl8 influenced the brown adipose tissue (BAT) morphology or uncoupling protein 1 (Ucp-1) expression in BAT. Taken together, these data suggested that Angptl8 modulates appetite and energy homeostasis.</p>