10.3389/fnmol.2018.00451.s001 Rui Wang Rui Wang Junhua Yuan Junhua Yuan Caishun Zhang Caishun Zhang Liuxin Wang Liuxin Wang Yuan Liu Yuan Liu Limin Song Limin Song Weizhen Zhong Weizhen Zhong Xi Chen Xi Chen Jing Dong Jing Dong Image_1_Neuropeptide Y-Positive Neurons in the Dorsomedial Hypothalamus Are Involved in the Anorexic Effect of Angptl8.TIF Frontiers 2018 Angptl8 neuropeptide Y appetite dorsomedial hypothalamus adipose tissue 2018-12-18 04:31:16 Figure https://frontiersin.figshare.com/articles/figure/Image_1_Neuropeptide_Y-Positive_Neurons_in_the_Dorsomedial_Hypothalamus_Are_Involved_in_the_Anorexic_Effect_of_Angptl8_TIF/7476893 <p>Angiopoietin-like protein 8 (Angptl8), a recently identified member of the angiopoietin-like protein family (ANGPTLs), is a 22-kDa peptide synthesized in the liver. It participates in lipid metabolism by inhibiting lipoprotein lipase (LPL) activity, consequently increasing the triglyceride levels. Despite evidence that Angptl8 is involved in feeding control, the underlying mechanisms are unclear. Central and peripheral injections of Angptl8 significantly decreased food intake. Angptl8 was widely expressed in appetite-related nuclei, including the paraventricular nucleus (PVN), the dorsomedial hypothalamus (DMH), the ventromedial hypothalamus, and the arcuate nucleus (ARC) in the hypothalamus. Peripheral Angptl8 administration decreased c-Fos-positive neurons in the DMH. Central Angptl8 administration decreased c-Fos-positive neurons in the DMH and PVN but increased these neurons in the ARC. Angptl8 inhibited appetite via neuropeptide Y (NPY) neurons in the DMH. Furthermore, the chronic administration of Angptl8 decreased body weight gain and altered adipose tissue deposits. Nevertheless, neither peripheral nor central Angptl8 influenced the brown adipose tissue (BAT) morphology or uncoupling protein 1 (Ucp-1) expression in BAT. Taken together, these data suggested that Angptl8 modulates appetite and energy homeostasis.</p>