10.3389/fimmu.2018.02550.s002
Rajeev K. Tyagi
Rajeev
K. Tyagi
Nikunj Tandel
Nikunj
Tandel
Richa Deshpande
Richa
Deshpande
Robert W. Engelman
Robert
W. Engelman
Satish D. Patel
Satish D.
Patel
Priyanka Tyagi
Priyanka
Tyagi
Image_1_Humanized Mice Are Instrumental to the Study of Plasmodium falciparum Infection.tif
Frontiers
2018
humanized/chimeric mice
malaria
NSG mice
TK/NOG mice
FRG mice
huRBCs
huHep
clodronate loaded liposomes
2018-12-13 04:07:26
Figure
https://frontiersin.figshare.com/articles/figure/Image_1_Humanized_Mice_Are_Instrumental_to_the_Study_of_Plasmodium_falciparum_Infection_tif/7459451
<p>Research using humanized mice has advanced our knowledge and understanding of human haematopoiesis, non-adaptive and adaptive immunity, autoimmunity, infectious disease, cancer biology, and regenerative medicine. Challenges posed by the human-malaria parasite Plasmodium falciparum include its complex life cycle, the evolution of drug resistance against anti-malarials, poor diagnosis, and a lack of effective vaccines. Advancements in genetically engineered and immunodeficient mouse strains, have allowed for studies of the asexual blood stage, exoerythrocytic stage and the transition from liver-to-blood stage infection, in a single vertebrate host. This review discusses the process of “humanization” of various immunodeficient/transgenic strains and their contribution to translational biomedical research. Our work reviews the strategies employed to overcome the remaining-limitations of the developed human-mouse chimera(s).</p>