10.3389/fimmu.2018.02813.s003
Markus Bardua
Markus
Bardua
Claudia Haftmann
Claudia
Haftmann
Pawel Durek
Pawel
Durek
Kerstin Westendorf
Kerstin
Westendorf
Antje Buttgereit
Antje
Buttgereit
Cam Loan Tran
Cam
Loan Tran
Mairi McGrath
Mairi
McGrath
Melanie Weber
Melanie
Weber
Katrin Lehmann
Katrin
Lehmann
Richard Kwasi Addo
Richard Kwasi
Addo
Gitta Anne Heinz
Gitta Anne
Heinz
Anna-Barbara Stittrich
Anna-Barbara
Stittrich
Patrick Maschmeyer
Patrick
Maschmeyer
Helena Radbruch
Helena
Radbruch
Michael Lohoff
Michael
Lohoff
Hyun-Dong Chang
Hyun-Dong
Chang
Andreas Radbruch
Andreas
Radbruch
Mir-Farzin Mashreghi
Mir-Farzin
Mashreghi
Table_2_MicroRNA-31 Reduces the Motility of Proinflammatory T Helper 1 Lymphocytes.xlsx
Frontiers
2018
CD4
miR-31
miRNA
target identification
T cell migration
Th1 cells
regulatory networks
antagomirs
2018-12-06 04:03:14
Dataset
https://frontiersin.figshare.com/articles/dataset/Table_2_MicroRNA-31_Reduces_the_Motility_of_Proinflammatory_T_Helper_1_Lymphocytes_xlsx/7428113
<p>Proinflammatory type 1 T helper (Th1) cells are enriched in inflamed tissues and contribute to the maintenance of chronic inflammation in rheumatic diseases. Here we show that the microRNA- (miR-) 31 is upregulated in murine Th1 cells with a history of repeated reactivation and in memory Th cells isolated from the synovial fluid of patients with rheumatic joint disease. Knock-down of miR-31 resulted in the upregulation of genes associated with cytoskeletal rearrangement and motility and induced the expression of target genes involved in T cell activation, chemokine receptor– and integrin-signaling. Accordingly, inhibition of miR-31 resulted in increased migratory activity of repeatedly activated Th1 cells. The transcription factors T-bet and FOXO1 act as positive and negative regulators of T cell receptor (TCR)–mediated miR-31 expression, respectively. Taken together, our data show that a gene regulatory network involving miR-31, T-bet, and FOXO1 controls the migratory behavior of proinflammatory Th1 cells.</p>