10.3389/fphar.2018.01098.s001 Lei Gao Lei Gao Peng Huang Peng Huang Zhaoyang Dong Zhaoyang Dong Tingting Gao Tingting Gao Shaohui Huang Shaohui Huang Chuying Zhou Chuying Zhou Yuling Lai Yuling Lai Guanghui Deng Guanghui Deng Bin Liu Bin Liu Ge Wen Ge Wen Zhiping Lv Zhiping Lv Data_Sheet_1_Modified Xiaoyaosan (MXYS) Exerts Anti-depressive Effects by Rectifying the Brain Blood Oxygen Level-Dependent fMRI Signals and Improving Hippocampal Neurogenesis in Mice.PDF Frontiers 2018 depression fMRI traditional Chinese medicine hippocampus blood oxygen level-dependent 2018-12-03 09:24:44 Dataset https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Modified_Xiaoyaosan_MXYS_Exerts_Anti-depressive_Effects_by_Rectifying_the_Brain_Blood_Oxygen_Level-Dependent_fMRI_Signals_and_Improving_Hippocampal_Neurogenesis_in_Mice_PDF/7410620 <p>As the traditional Chinese herbal formula, Xiaoyaosan and its modified formula have been described in many previous studies with definite anti-depressive effects, but its underlying mechanism remains mystery. Previous work in our lab has demonstrated that depression induced by chronic stress could generate brain blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals disorder, accompanied by the impairment of hippocampal neuronal plasticity, decrease of brain-derived neurotrophic factor, and reduction of the number and complexity of adult neurons in the dentate gyrus. We hypothesized that herbal formula based on Xiaoyaosan could exert anti-depressive effects through restoring these neurobiological dysfunctions and rectifying BOLD-fMRI signals. To test this hypothesis, we examined the effect of modified Xiaoyaosan (MXYS) on depressive-like behaviors, as well as hippocampal neurogenesis and BOLD signals in a mice model of chronic unpredictable mild stress (CUMS)-induced depression. MXYS exerted anti-depressant effects on CUMS-induced depression that were similar to the effects of classical antidepressants drug (fluoxetine hydrochloride), with a significant alleviation of depressive-like behaviors, an improvement of hippocampal neurogenesis, and a reversal of activation of BOLD in the limbic system, particularly in the hippocampus. These results suggested that MXYS attenuated CUMS-induced depressive behaviors by rectifying the BOLD signals in the mice hippocampus. These novel results demonstrated that MXYS had anti-depressive effects accompanied by improving BOLD signals and hippocampal neurogenesis, which suggested that BOLD-fMRI signals in brain regions could be a key component for the evaluation of novel antidepressant drugs.</p>