10.3389/fnins.2018.00889.s001
Yun-Hui Chen
Yun-Hui
Chen
Su-Fang Li
Su-Fang
Li
Dan Lv
Dan
Lv
Gui-Dong Zhu
Gui-Dong
Zhu
Yu-Hua Wang
Yu-Hua
Wang
Xin Meng
Xin
Meng
Qiang Hu
Qiang
Hu
Cheng-Chong Li
Cheng-Chong
Li
Liang-Tang Zhang
Liang-Tang
Zhang
Xiang-Ping Chu
Xiang-Ping
Chu
Xiao-Ping Wang
Xiao-Ping
Wang
Ping Li
Ping
Li
Data_Sheet_1_Decreased Intrinsic Functional Connectivity of the Salience Network in Drug-Naïve Patients With Obsessive-Compulsive Disorder.doc
Frontiers
2018
obsessive-compulsive disorder
salience network
resting-state
functional magnetic resonance imaging
intrinsic functional connectivity
2018-11-28 04:36:54
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Decreased_Intrinsic_Functional_Connectivity_of_the_Salience_Network_in_Drug-Na_ve_Patients_With_Obsessive-Compulsive_Disorder_doc/7391594
<p>Obsessive-compulsive disorder (OCD) patients have difficulty in switching between obsessive thought and compulsive behavior, which may be related to the dysfunction of the salience network (SN). However, little is known about the changes in intra- and inter- intrinsic functional connectivity (iFC) of the SN in patients with OCD. In this study, we parceled the SN into 19 subregions and investigated iFC changes for each of these subregions in 40 drug-naïve patients with OCD and 40 healthy controls (HCs) using seed-based functional connectivity resting-state functional magnetic resonance imaging (rs-fMRI). We found that patients with OCD exhibited decreased iFC strength between subregions of the SN, as well as decreased inter-network connectivity between SN and DMN, and ECN. These findings highlight a specific alteration in iFC patterns associated with SN in patients with OCD and provide new insights into the dysfunctional brain organization of the SN in patients with OCD.</p>