10.3389/fnins.2018.00889.s001 Yun-Hui Chen Yun-Hui Chen Su-Fang Li Su-Fang Li Dan Lv Dan Lv Gui-Dong Zhu Gui-Dong Zhu Yu-Hua Wang Yu-Hua Wang Xin Meng Xin Meng Qiang Hu Qiang Hu Cheng-Chong Li Cheng-Chong Li Liang-Tang Zhang Liang-Tang Zhang Xiang-Ping Chu Xiang-Ping Chu Xiao-Ping Wang Xiao-Ping Wang Ping Li Ping Li Data_Sheet_1_Decreased Intrinsic Functional Connectivity of the Salience Network in Drug-Naïve Patients With Obsessive-Compulsive Disorder.doc Frontiers 2018 obsessive-compulsive disorder salience network resting-state functional magnetic resonance imaging intrinsic functional connectivity 2018-11-28 04:36:54 Dataset https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Decreased_Intrinsic_Functional_Connectivity_of_the_Salience_Network_in_Drug-Na_ve_Patients_With_Obsessive-Compulsive_Disorder_doc/7391594 <p>Obsessive-compulsive disorder (OCD) patients have difficulty in switching between obsessive thought and compulsive behavior, which may be related to the dysfunction of the salience network (SN). However, little is known about the changes in intra- and inter- intrinsic functional connectivity (iFC) of the SN in patients with OCD. In this study, we parceled the SN into 19 subregions and investigated iFC changes for each of these subregions in 40 drug-naïve patients with OCD and 40 healthy controls (HCs) using seed-based functional connectivity resting-state functional magnetic resonance imaging (rs-fMRI). We found that patients with OCD exhibited decreased iFC strength between subregions of the SN, as well as decreased inter-network connectivity between SN and DMN, and ECN. These findings highlight a specific alteration in iFC patterns associated with SN in patients with OCD and provide new insights into the dysfunctional brain organization of the SN in patients with OCD.</p>