10.3389/fnmol.2018.00429.s001
Alejandra Arias-Cavieres
Alejandra
Arias-Cavieres
Jamileth More
Jamileth
More
José Miguel Vicente
José Miguel
Vicente
Tatiana Adasme
Tatiana
Adasme
Jorge Hidalgo
Jorge
Hidalgo
José Luis Valdés
José Luis
Valdés
Alexis Humeres
Alexis
Humeres
Ismael Valdés-Undurraga
Ismael
Valdés-Undurraga
Gina Sánchez
Gina
Sánchez
Cecilia Hidalgo
Cecilia
Hidalgo
Genaro Barrientos
Genaro
Barrientos
Table_1_Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats.DOCX
Frontiers
2018
hippocampus
structural plasticity
Ca2+ signals
synaptic transmission
antimicrobial agents
2018-11-26 04:08:08
Dataset
https://frontiersin.figshare.com/articles/dataset/Table_1_Triclosan_Impairs_Hippocampal_Synaptic_Plasticity_and_Spatial_Memory_in_Male_Rats_DOCX/7380173
<p>Triclosan, a widely used industrial and household agent, is present as an antiseptic ingredient in numerous products of everyday use, such as toothpaste, cosmetics, kitchenware, and toys. Previous studies have shown that human brain and animal tissues contain triclosan, which has been found also as a contaminant of water and soil. Triclosan disrupts heart and skeletal muscle Ca<sup>2+</sup> signaling, damages liver function, alters gut microbiota, causes colonic inflammation, and promotes apoptosis in cultured neocortical neurons and neural stem cells. Information, however, on the possible effects of triclosan on the function of the hippocampus, a key brain region for spatial learning and memory, is lacking. Here, we report that triclosan addition at low concentrations to hippocampal slices from male rats inhibited long-term potentiation but did not affect basal synaptic transmission or paired-pulse facilitation and modified the content or phosphorylation levels of synaptic plasticity-related proteins. Additionally, incubation of primary hippocampal cultures with triclosan prevented both the dendritic spine remodeling induced by brain-derived neurotrophic factor and the emergence of spontaneous oscillatory Ca<sup>2+</sup> signals. Furthermore, intra-hippocampal injection of triclosan significantly disrupted rat navigation in the Oasis maze spatial memory task, an indication that triclosan impairs hippocampus-dependent spatial memory performance. Based on these combined results, we conclude that triclosan exerts highly damaging effects on hippocampal neuronal function in vitro and impairs spatial memory processes in vivo.</p>