10.3389/fphys.2018.01549.s002 Wei-Ling He Wei-Ling He Xiang-Tao Weng Xiang-Tao Weng Jue-Lian Wang Jue-Lian Wang Yong-Kai Lin Yong-Kai Lin Tian-Wen Liu Tian-Wen Liu Qian-Yi Zhou Qian-Yi Zhou Yue Hu Yue Hu Yunbao Pan Yunbao Pan Xin-Lin Chen Xin-Lin Chen Table_2_Association Between c-Myc and Colorectal Cancer Prognosis: A Meta-Analysis.DOC Frontiers 2018 c-Myc colorectal cancer prognosis biomarker meta-analysis 2018-11-13 17:03:34 Dataset https://frontiersin.figshare.com/articles/dataset/Table_2_Association_Between_c-Myc_and_Colorectal_Cancer_Prognosis_A_Meta-Analysis_DOC/7335140 <p>Background: There is debate as to whether c-Myc predicts prognosis in colorectal cancer (CRC). In this study, we aimed to review the association between c-Myc and CRC prognosis.</p><p>Methods: Pertinent studies were identified by searching electronic databases and carefully reviewing the reference lists of pertinent studies until March 2016. The summary hazard ratio (HR) and corresponding 95% confidence interval (CI) were calculated to study the association between c-Myc and CRC prognosis.</p><p>Results: Eight cohort studies (including seven studies about overall survival [OS] and one study about disease free survival [DFS]) were included. The pooled HR of OS was 1.13 (95% CI: 0.66–1.95). In subgroup analysis, no significant association between c-Myc and CRC prognosis was found in the studies either from Western countries (HR: 0.87, 95% CI: 0.68–1.10) or Asian countries (HR: 1.89, 95% CI: 0.62–5.77). HRs were 0.86 (95% CI: 0.38–1.94) and 1.57 (95% CI: 0.73–3.39) for the studies using univariate analysis and multivariate analysis, respectively. HR from the studies that examined DNA level was significantly different (HR: 2.05, 95% CI: 1.22–3.46); while that about RNA level or protein level was not significantly different.</p><p>Conclusion: c-Myc was not associated with CRC prognosis in this meta-analysis. However, the conclusion is preliminary and should be examined in future studies.</p>