10.3389/fphys.2018.01549.s002
Wei-Ling He
Wei-Ling
He
Xiang-Tao Weng
Xiang-Tao
Weng
Jue-Lian Wang
Jue-Lian
Wang
Yong-Kai Lin
Yong-Kai
Lin
Tian-Wen Liu
Tian-Wen
Liu
Qian-Yi Zhou
Qian-Yi
Zhou
Yue Hu
Yue
Hu
Yunbao Pan
Yunbao
Pan
Xin-Lin Chen
Xin-Lin
Chen
Table_2_Association Between c-Myc and Colorectal Cancer Prognosis: A Meta-Analysis.DOC
Frontiers
2018
c-Myc
colorectal cancer
prognosis
biomarker
meta-analysis
2018-11-13 17:03:34
Dataset
https://frontiersin.figshare.com/articles/dataset/Table_2_Association_Between_c-Myc_and_Colorectal_Cancer_Prognosis_A_Meta-Analysis_DOC/7335140
<p>Background: There is debate as to whether c-Myc predicts prognosis in colorectal cancer (CRC). In this study, we aimed to review the association between c-Myc and CRC prognosis.</p><p>Methods: Pertinent studies were identified by searching electronic databases and carefully reviewing the reference lists of pertinent studies until March 2016. The summary hazard ratio (HR) and corresponding 95% confidence interval (CI) were calculated to study the association between c-Myc and CRC prognosis.</p><p>Results: Eight cohort studies (including seven studies about overall survival [OS] and one study about disease free survival [DFS]) were included. The pooled HR of OS was 1.13 (95% CI: 0.66–1.95). In subgroup analysis, no significant association between c-Myc and CRC prognosis was found in the studies either from Western countries (HR: 0.87, 95% CI: 0.68–1.10) or Asian countries (HR: 1.89, 95% CI: 0.62–5.77). HRs were 0.86 (95% CI: 0.38–1.94) and 1.57 (95% CI: 0.73–3.39) for the studies using univariate analysis and multivariate analysis, respectively. HR from the studies that examined DNA level was significantly different (HR: 2.05, 95% CI: 1.22–3.46); while that about RNA level or protein level was not significantly different.</p><p>Conclusion: c-Myc was not associated with CRC prognosis in this meta-analysis. However, the conclusion is preliminary and should be examined in future studies.</p>