10.3389/fped.2018.00315.s010
Luana Abballe
Luana
Abballe
Angela Mastronuzzi
Angela
Mastronuzzi
Evelina Miele
Evelina
Miele
Andrea Carai
Andrea
Carai
Zein Mersini Besharat
Zein Mersini
Besharat
Marta Moretti
Marta
Moretti
Enrico De Smaele
Enrico
De Smaele
Felice Giangaspero
Felice
Giangaspero
Franco Locatelli
Franco
Locatelli
Elisabetta Ferretti
Elisabetta
Ferretti
Agnese Po
Agnese
Po
Image_9_Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells.JPEG
Frontiers
2018
medulloblastoma
numb
NUMB isoforms
cancer stem cells
neural stem cells
sonic hedgehog signaling
2018-11-01 04:17:30
Figure
https://frontiersin.figshare.com/articles/figure/Image_9_Numb_Isoforms_Deregulation_in_Medulloblastoma_and_Role_of_p66_Isoform_in_Cancer_and_Neural_Stem_Cells_JPEG/7283969
<p>Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal expression has been described in several types of cancer. Involvement of deregulated Numb expression has been described in the malignant childhood brain tumor medulloblastoma, while Numb isoforms in these tumors and in cancer stem-like cells derived from them, have not been studied to date. Here we show that medulloblastoma stem-like cells and cerebellar neuronal stem cells (NSCs) express Numb p66 where its expression tampers stemness features. Furthermore, medulloblastoma samples evaluated in this study express decreased levels of Numb p66 while overexpressed Numb p72 compared with normal tissues. Our results uncover different roles for the two major Numb isoforms examined in medulloblastoma and a critical role for Numb p66 in regulating stem-like cells and NSCs maintenance.</p>