10.3389/fimmu.2018.02362.s002
Junping Yin
Junping
Yin
Junfeng Zheng
Junfeng
Zheng
Fengyuan Deng
Fengyuan
Deng
Wenjie Zhao
Wenjie
Zhao
Yan Chen
Yan
Chen
Qiaoniang Huang
Qiaoniang
Huang
Renliang Huang
Renliang
Huang
Lifang Wen
Lifang
Wen
Xiaoyang Yue
Xiaoyang
Yue
Frank Petersen
Frank
Petersen
Xinhua Yu
Xinhua
Yu
Table_1_Gene Expression Profiling of Lacrimal Glands Identifies the Ectopic Expression of MHC II on Glandular Cells as a Presymptomatic Feature in a Mouse Model of Primary Sjögren's Syndrome.xlsx
Frontiers
2018
primary Sjögren's syndrome
mouse model
presymptomatic feature
MHC II ectopic expression
TiterMax®
adjuvant
2018-10-31 11:59:30
Dataset
https://frontiersin.figshare.com/articles/dataset/Table_1_Gene_Expression_Profiling_of_Lacrimal_Glands_Identifies_the_Ectopic_Expression_of_MHC_II_on_Glandular_Cells_as_a_Presymptomatic_Feature_in_a_Mouse_Model_of_Primary_Sj_gren_s_Syndrome_xlsx/7275710
<p>Ectopic expression of MHC II molecules on glandular cells is a feature of primary Sjögren's syndrome (pSS). However, the cause of this ectopic expression and its potential role in the pathogenesis of the disease remains elusive. Here, we report that ectopic expression of MHC II molecules on glandular cells represents an early presymptomatic event in a mouse model of pSS induced by immunization of Ro60_316-335 peptide emulsified in TiterMax® as an adjuvant. Ectopic expression of MHC II was induced by TiterMax® but not by complete freund's adjuvant (CFA). Furthermore, immunization with Ro60_316-335 peptide emulsified in TiterMax®, but not in CFA, induced a pSS-like disease in mice. Our results suggests that ectopic expression of MHC II molecules on glandular cells represents a presymptomatic feature of pSS and that such ectopic expression can be induced by exogenous factors. In addition, this study also provides a novel mechanism how adjuvants can amplify immune responses.</p>