Tse, Gary Li, Ka Hou Christien Li, Guangping Liu, Tong Bazoukis, George Wong, Wing Tak T. V. Chan, Matthew C. S. Wong, Martin Xia, Yunlong Letsas, Konstantinos P. Chan, Gary Chin Pang Chan, Yat Sun K. K. Wu, William Data_Sheet_1_Higher Dispersion Measures of Conduction and Repolarization in Type 1 Compared to Non-type 1 Brugada Syndrome Patients: An Electrocardiographic Study From a Single Center.PDF <p>Background: Brugada syndrome (BrS) is a cardiac ion channelopathy that predisposes affected individuals to sudden cardiac death (SCD). Type 1 BrS is thought to take a more malignant clinical course than non-type 1 BrS. We hypothesized that the degrees of abnormal repolarization and conduction are greater in type 1 subjects and these differences can be detected by electrocardiography (ECG).</p><p>Methods: Electrocardiographic data from spontaneous type 1 and non-type 1 BrS patients were analyzed. ECG parameters were measured from leads V1 to V3. Values were expressed as median [lower quartile-upper quartile] and compared using Kruskal-Wallis ANOVA.</p><p>Results: Compared to non-type 1 BrS patients (n = 29), patients with spontaneous type 1 patterns (n = 22) showed similar (P > 0.05) heart rate (73 [64–77] vs. 68 [62–80] bpm), QRS duration (136 [124–161] vs. 127 [117–144] ms), uncorrected QT (418 [393–443] vs. 402 [386–424] ms) and corrected QT intervals (457 [414–474] vs. 430 [417–457] ms), JT<sub>peak</sub> intervals (174 [144–183] vs. 174 [150–188] ms), T<sub>peak−</sub> T<sub>end</sub> intervals (101 [93–120] vs. 99 [90–105] ms), T<sub>peak−</sub> T<sub>end</sub>/QT ratios (0.25 [0.23–0.27] vs. 0.24 [0.22–0.27]), T<sub>peak−</sub> T<sub>end</sub>/QRS (0.77 [0.62–0.87] vs. 0.77 [0.69–0.86]), T<sub>peak−</sub> T<sub>end</sub>/(QRS × QT) (0.00074 [0.00034–0.00096] vs. 0.00073 [0.00048–0.00012] ms<sup>−1</sup>), index of Cardiac Electrophysiological Balance (iCEB, QT/QRS, marker of wavelength: 3.14 [2.56–3.35] vs. 3.21 [2.85–3.46]) and corrected iCEB (QTc/QRS: 3.25 [2.91–3.73] vs. 3.49 [2.99–3.78]). Higher QRS dispersion was seen in type 1 subjects (QRSd: 34 [24–66] vs. 24 [12–34] ms) but QT dispersion (QTd: 48 [39–71] vs. 43 [22–94] ms), QTc dispersion (QTcd: 52 [41–79] vs. 46 [23–104] ms), JT<sub>peak</sub> dispersion (44 [23–62] vs. 45 [30–62] ms), T<sub>peak−</sub> T<sub>end</sub> dispersion (28 [15–34] vs. 29 [22–53] ms) or T<sub>peak−</sub> T<sub>end</sub>/QT dispersion (0.06 [0.03–0.08] vs. 0.08 [0.04–0.12]) did not differ between the two groups. Type 1 subjects showed higher (QRSd × T<sub>peak−</sub> T<sub>end</sub>)/QRS (25 [19–44] vs. 19 [9–30] ms) but similar iCEB dispersion (0.83 [0.49–1.14] vs. 0.61 [0.34–0.92]) and iCEBc dispersion (0.93 [0.51–1.15] vs. 0.65 [0.39–0.96]).</p><p>Conclusion: Higher levels of dispersion in conduction and repolarization are found in type 1 than non-type 1 BrS patients, potentially explaining the higher incidence of ventricular arrhythmias in the former group.</p> electrocardiography;conduction;repolarization;wavelength;Brugada syndrome 2018-10-04
    https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Higher_Dispersion_Measures_of_Conduction_and_Repolarization_in_Type_1_Compared_to_Non-type_1_Brugada_Syndrome_Patients_An_Electrocardiographic_Study_From_a_Single_Center_PDF/7163711
10.3389/fcvm.2018.00132.s001