10.3389/fmicb.2018.02283.s002
Nivea F. Luz
Nivea F.
Luz
Ricardo Khouri
Ricardo
Khouri
Johan Van Weyenbergh
Johan
Van Weyenbergh
Dalila L. Zanette
Dalila
L. Zanette
Paloma P. Fiuza
Paloma P.
Fiuza
Almerio Noronha
Almerio
Noronha
Aldina Barral
Aldina
Barral
Viviane S. Boaventura
Viviane
S. Boaventura
Deboraci B. Prates
Deboraci
B. Prates
Francis Ka-Ming Chan
Francis
Ka-Ming Chan
Bruno B. Andrade
Bruno
B. Andrade
Valeria M. Borges
Valeria
M. Borges
Image_2_Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression.TIFF
Frontiers
2018
RIPK3
MLKL
macrophage
necroptosis
Leishmania braziliensis
2018-09-28 04:14:03
Figure
https://frontiersin.figshare.com/articles/figure/Image_2_Leishmania_braziliensis_Subverts_Necroptosis_by_Modulating_RIPK3_Expression_TIFF/7144943
<p>Leishmania braziliensis infection causes skin ulcers, typically found in localized cutaneous leishmaniasis (LCL). This tissue pathology associates with different modalities of cell necrosis, which are subverted by the parasite as a survival strategy. Herein we examined the participation of necroptosis, a specific form of programmed necrosis, in LCL lesions and found reduced RIPK3 and PGAM5 gene expression compared to normal skin. Assays using infected macrophages demonstrated that the parasite deactivates both RIPK3 and MLKL expression and that these molecules are important to control the intracellular L. braziliensis replication. Thus, LCL-related necroptosis may be targeted to control infection and disease immunopathology.</p>