Table_1_Leptin Selectively Regulates Nutrients Metabolism in Nile Tilapia Fed on High Carbohydrate or High Fat Diet.DOCX Cai-Zhi Liu An-Yuan He Li-Jun Ning Yuan Luo Dong-Liang Li Mei-Ling Zhang Li-Qiao Chen Zhen-Yu Du 10.3389/fendo.2018.00574.s002 https://frontiersin.figshare.com/articles/dataset/Table_1_Leptin_Selectively_Regulates_Nutrients_Metabolism_in_Nile_Tilapia_Fed_on_High_Carbohydrate_or_High_Fat_Diet_DOCX/7138478 <p>Leptin is known to inhibit appetite and promote energy metabolism in vertebrates. Leptin resistance (LR) commonly occurs in diet-induced obesity (DIO) in mammals. However, the roles of leptin in the energy homeostasis in DIO animals with LR remain unclear. Here we first verified the high expression of leptin in subcutaneous adipose tissue (SCAT) as in liver in Nile tilapia. Furthermore, we produced two types of DIO Nile tilapia by using a high-carbohydrate diet (HCD) or a high-fat diet (HFD), and confirmed the existence of LR in both models. Notably, we found that HCD-DIO fish retained leptin action in the activation of lipid metabolism and showed LR in glucose metabolism regulation, while this selective leptin action between lipid and glucose metabolism was reversed in HFD-DIO fish. Fasting the fish for 1 week completely recovered leptin actions in the regulation of lipid and glucose metabolism. Therefore, leptin may retain more of its activities in animals with LR than previously believed. Evolutionally, this selective regulation of leptin in nutrients metabolism could be an adaptive mechanism in animals to store surplus calories when different types of food are abundant.</p> 2018-09-27 04:10:04 leptin resistance DIO teleost selective regulation lipid metabolism glucose metabolism