10.3389/fncel.2018.00198.s001
Yukyeong Lee
Yukyeong
Lee
C-Yoon Kim
C-Yoon
Kim
Hye Jeong Lee
Hye Jeong
Lee
Jae Gon Kim
Jae
Gon Kim
Dong Wook Han
Dong
Wook Han
Kisung Ko
Kisung
Ko
James Walter
James
Walter
Hyung-Min Chung
Hyung-Min
Chung
Hans R. Schöler
Hans
R. Schöler
Young Min Bae
Young
Min Bae
Kinarm Ko
Kinarm
Ko
Image_1_Two-Step Generation of Oligodendrocyte Progenitor Cells From Mouse Fibroblasts for Spinal Cord Injury.pdf
Frontiers
2018
oligodendrocyte progenitor cells
oligodendrocytes
neural stem cells
direct-converted neural stem cells
spinal cord injury
2018-07-25 15:41:08
Figure
https://frontiersin.figshare.com/articles/figure/Image_1_Two-Step_Generation_of_Oligodendrocyte_Progenitor_Cells_From_Mouse_Fibroblasts_for_Spinal_Cord_Injury_pdf/6860657
<p>Oligodendrocyte progenitor cells (OPCs) are attracting attention as the ideal cell therapy for spinal cord injury (SCI). Recently, advanced reprogramming and differentiation techniques have made it possible to generate therapeutic cells for treating SCI. In the present study, we used directly-induced neural stem cells (DNSCs) from fibroblasts to establish OPCs (DN-OPCs) capable of proliferation and confirmed their OPC-specific characteristics. Also, we evaluated the effect of transplanted DN-OPCs on SCI in rats. The DN-OPCs exhibited an OPC-specific phenotype and electrophysiological function and could be differentiated into oligodendrocytes. In the SCI model, transplanted DN-OPCs improved behavior recovery, and showed engraftment into the host spinal cord with expression of myelin basic protein. These results suggest that DN-OPCs could be a new source of potentially useful cells for treating SCI.</p>