Table_1_Incidence, Outcome, and Predictors of Intracranial Hemorrhage in Adult Patients on Extracorporeal Membrane Oxygenation: A Systematic and Narrative Review.DOCX Alexander Fletcher-Sandersjöö Eric Peter Thelin Jiri Bartek Mikael Broman Marko Sallisalmi Adrian Elmi-Terander Bo-Michael Bellander 10.3389/fneur.2018.00548.s001 https://frontiersin.figshare.com/articles/dataset/Table_1_Incidence_Outcome_and_Predictors_of_Intracranial_Hemorrhage_in_Adult_Patients_on_Extracorporeal_Membrane_Oxygenation_A_Systematic_and_Narrative_Review_DOCX/6753164 <p>Background: Intracranial hemorrhage (ICH) is a common complication in adults treated with extracorporeal membrane oxygenation (ECMO).</p><p>Objectives: The aim of this study was to conduct a systematic review of the literature on the incidence, outcome and predictors of ECMO-associated ICH in adult patients, supplemented by a narrative review of its pathophysiology, management and future perspectives.</p><p>Methods: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews and www.clinicaltrials.gov were systematically searched. Studies that reported incidence, outcome or predictors of ECMO-associated ICH in adults (≥18 years) were eligible for inclusion.</p><p>Results: Twenty five articles were included in the systematic review. The incidence of ECMO-associated ICH varied between 1.8 and 21 %. Mortality rates in ICH-cohorts varied between 32 and 100 %, with a relative risk of mortality of 1.27–4.43 compared to non-ICH cohorts. An increased risk of ICH was associated with ECMO-duration, antithrombotic therapy, altered intrinsic coagulation, renal failure, need of blood products, rapid hypercapnia at ECMO initiation, and even pre-ECMO morbidity.</p><p>Conclusions: ICH is a common complication in adults treated with ECMO and associated with increased mortality. Treating an ICH during ECMO represents a balance between pro- and anticoagulatory demands. Neurosurgical treatment is associated with severe morbidity, but has been successful in selected cases. Future studies should aim at investigating the validity and feasibility of non-invasive monitoring in early detection of ECMO-associated ICH.</p> 2018-07-06 04:14:27 intracranial hemorrhage intracerebral hemorrhage brain injury neurological injury extracorporeal membrane oxygenation extracorporeal life support adults