10.3389/fcimb.2018.00202.s001
Juan-Juan Gao
Juan-Juan
Gao
Yang Zhang
Yang
Zhang
Markus Gerhard
Markus
Gerhard
Raquel Mejias-Luque
Raquel
Mejias-Luque
Lian Zhang
Lian
Zhang
Michael Vieth
Michael
Vieth
Jun-Ling Ma
Jun-Ling
Ma
Monther Bajbouj
Monther
Bajbouj
Stepan Suchanek
Stepan
Suchanek
Wei-Dong Liu
Wei-Dong
Liu
Kurt Ulm
Kurt
Ulm
Michael Quante
Michael
Quante
Zhe-Xuan Li
Zhe-Xuan
Li
Tong Zhou
Tong
Zhou
Roland Schmid
Roland
Schmid
Meinhard Classen
Meinhard
Classen
Wen-Qing Li
Wen-Qing
Li
Wei-Cheng You
Wei-Cheng
You
Kai-Feng Pan
Kai-Feng
Pan
Data_Sheet_1_Association Between Gut Microbiota and Helicobacter pylori-Related Gastric Lesions in a High-Risk Population of Gastric Cancer.docx
Frontiers
2018
Helicobacter pylori
gastric lesions
gut microbiota
microbial diversity
16S ribosomal RNA gene sequencing
2018-06-19 04:38:39
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Association_Between_Gut_Microbiota_and_Helicobacter_pylori-Related_Gastric_Lesions_in_a_High-Risk_Population_of_Gastric_Cancer_docx/6599087
<p>Eradication of Helicobacter pylori has been found to be effective for gastric cancer prevention, but uncertainties remain about the possible adverse consequences such as the potential microbial dysbiosis. In our study, we investigated the association between gut microbiota and H. pylori-related gastric lesions in 47 subjects by deep sequencing of microbial 16S ribosomal RNA (rRNA) gene in fecal samples. The dominant phyla in fecal samples were Bacteroidetes, Firmicutes, and Proteobacteria with average relative abundances of 54.77, 31.37 and 12.91%, respectively. Microbial diversity analysis showed that observed species and Shannon index were increased in subjects with past or current H. pylori infection compared with negative subjects. As for the differential bacteria, the average relative abundance of Bacteroidetes was found to significantly decrease from H. pylori negative (66.16%) to past infection group (33.01%, p = 0.007), as well as from normal (76.49%) to gastritis (56.04%) and metaplasia subjects (46.83%, p = 0.027). For Firmicutes and Proteobacteria, the average relative abundances showed elevated trends in the past H. pylori infection group (47.11, 20.53%) compared to negative group (23.44, 9.05%, p = 0.068 and 0.246, respectively), and similar increased trends were also found from normal (18.23, 5.05%) to gastritis (35.31, 7.23%, p = 0.016 and 0.294, respectively) or metaplasia subjects (32.33, 20.07%, both p < 0.05). These findings suggest that the alterations of fecal microbiota, especially the dominant phyla of Bacteroidetes, Firmicutes and Proteobacteria, may be involved in the process of H. pylori-related gastric lesion progression and provide hints for future evaluation of microbial changes after H. pylori eradication.</p>