10.3389/fnagi.2018.00167.s001
Chao-Qun Yan
Chao-Qun
Yan
Cun-Zhi Liu
Cun-Zhi
Liu
Xu Wang
Xu
Wang
Jian-Wei Huo
Jian-Wei
Huo
Ping Zhou
Ping
Zhou
Shuai Zhang
Shuai
Zhang
Qing-Nan Fu
Qing-Nan
Fu
Jie Zhang
Jie
Zhang
Zhong-Yan Wang
Zhong-Yan
Wang
Qing-Quan Liu
Qing-Quan
Liu
Image_1_Abnormal Functional Connectivity of Anterior Cingulate Cortex in Patients With Primary Insomnia: A Resting-State Functional Magnetic Resonance Imaging Study.TIF
Frontiers
2018
primary insomnia
voxel-mirrored homotopic connectivity
functional connectivity
anterior cingulate cortex
resting-state fMRI
2018-06-05 04:17:50
Figure
https://frontiersin.figshare.com/articles/figure/Image_1_Abnormal_Functional_Connectivity_of_Anterior_Cingulate_Cortex_in_Patients_With_Primary_Insomnia_A_Resting-State_Functional_Magnetic_Resonance_Imaging_Study_TIF/6443144
<p>Background: Recently, there have been many reports about abnormalities regarding structural and functional brain connectivity of the patients with primary insomnia. However, the alterations in functional interaction between the left and right cerebral hemispheres have not been well understood. The resting-state fMRI approach, which reveals spontaneous neural fluctuations in blood-oxygen-level-dependent signals, offers a method to quantify functional interactions between the hemispheres directly.</p><p>Methods: We compared interhemispheric functional connectivity (FC) between 26 patients with primary insomnia (48.85 ± 12.02 years) and 28 healthy controls (49.07 ± 11.81 years) using a voxel-mirrored homotopic connectivity (VMHC) method. The patients with primary insomnia and healthy controls were matched for age, gender, and education. Brain regions, which had significant differences in VMHC maps between the primary insomnia and healthy control groups, were defined as seed region of interests. A seed-based approach was further used to reveal significant differences of FC between the seeds and the whole contralateral hemisphere.</p><p>Results: The patients with primary insomnia showed higher VMHC than healthy controls in the anterior cingulate cortex (ACC) bilaterally. The seed-based analyses demonstrated increased FC between the left ACC and right thalamus (and the right ACC and left orbitofrontal cortex) in patients with primary insomnia, revealing abnormal connectivity between the two cerebral hemispheres. The VMHC values in the ACC were positively correlated with the time to fall asleep and Self-Rating Depression Scale scores (SDS).</p><p>Conclusions: The results demonstrate that there is abnormal interhemispheric resting-state FC in the brain regions of patients with primary insomnia, especially in the ACC. Our finding demonstrates valid evidence that the ACC is an area of interest in the neurobiology of primary insomnia.</p>