10.3389/fpsyt.2018.00209.s003 Adriano Aquino Adriano Aquino Guilherme L. Alexandrino Guilherme L. Alexandrino Paul C. Guest Paul C. Guest Fabio Augusto Fabio Augusto Alexandre F. Gomes Alexandre F. Gomes Michael Murgu Michael Murgu Johann Steiner Johann Steiner Daniel Martins-de-Souza Daniel Martins-de-Souza Table_3_Blood-Based Lipidomics Approach to Evaluate Biomarkers Associated With Response to Olanzapine, Risperidone, and Quetiapine Treatment in Schizophrenia Patients.XLSX Frontiers 2018 schizophrenia drug response antipsychotics lipidomics biomarkers 2018-05-25 12:32:41 Dataset https://frontiersin.figshare.com/articles/dataset/Table_3_Blood-Based_Lipidomics_Approach_to_Evaluate_Biomarkers_Associated_With_Response_to_Olanzapine_Risperidone_and_Quetiapine_Treatment_in_Schizophrenia_Patients_XLSX/6355916 <p>This is the first study to identify lipidomic markers in plasma associated with response of acutely ill schizophrenia patients in response to specific antipsychotic treatments. The study population included 54 schizophrenia patients treated with antipsychotics for 6 weeks. Treatment led to significant improvement in positive and negative symptoms for 34 patients with little or no improvement for 20 patients. In addition, 37 patients showed an increase in body mass index after the 6 week treatment period, consistent with effects on metabolism and the association of such effects with symptom improvement. Profiling of plasma samples taken prior to therapy using liquid chromatography tandem mass spectrometry (LC-MS/MS) resulted in identification of 38, 10, and 52 compounds associated with the olanzapine, risperidone, and quetiapine treatment groups, which could be used to distinguish responders from non-responders. Limitations include the retroactive active nature of the study and the small sample size. Further investigations with larger sample sets could lead to the development of a molecular test that could be used to help psychiatrists determine the best treatment options for each patient.</p>