10.3389/fgene.2018.00118.s006
Song-Song Xu
Song-Song
Xu
Lei Gao
Lei
Gao
Xing-Long Xie
Xing-Long
Xie
Yan-Ling Ren
Yan-Ling
Ren
Zhi-Qiang Shen
Zhi-Qiang
Shen
Feng Wang
Feng
Wang
Min Shen
Min
Shen
Emma Eyϸórsdóttir
Emma
Eyϸórsdóttir
Jón H. Hallsson
Jón H.
Hallsson
Tatyana Kiseleva
Tatyana
Kiseleva
Juha Kantanen
Juha
Kantanen
Meng-Hua Li
Meng-Hua
Li
Table_1.XLSX
Frontiers
2018
sheep
prolificacy
genome-wide association study
biological pathways
regulation
2018-04-10 11:52:22
Dataset
https://frontiersin.figshare.com/articles/dataset/Table_1_XLSX/6121043
<p>Reproduction is an important trait in sheep breeding as well as in other livestock. However, despite its importance the genetic mechanisms of litter size in domestic sheep (Ovis aries) are still poorly understood. To explore genetic mechanisms underlying the variation in litter size, we conducted multiple independent genome-wide association studies in five sheep breeds of high prolificacy (Wadi, Hu, Icelandic, Finnsheep, and Romanov) and one low prolificacy (Texel) using the Ovine Infinium HD BeadChip, respectively. We identified different sets of candidate genes associated with litter size in different breeds: BMPR1B, FBN1, and MMP2 in Wadi; GRIA2, SMAD1, and CTNNB1 in Hu; NCOA1 in Icelandic; INHBB, NF1, FLT1, PTGS2, and PLCB3 in Finnsheep; ESR2 in Romanov and ESR1, GHR, ETS1, MMP15, FLI1, and SPP1 in Texel. Further annotation of genes and bioinformatics analyses revealed that different biological pathways could be involved in the variation in litter size of females: hormone secretion (FSH and LH) in Wadi and Hu, placenta and embryonic lethality in Icelandic, folliculogenesis and LH signaling in Finnsheep, ovulation and preovulatory follicle maturation in Romanov, and estrogen and follicular growth in Texel. Taken together, our results provide new insights into the genetic mechanisms underlying the prolificacy trait in sheep and other mammals, suggesting targets for selection where the aim is to increase prolificacy in breeding projects.</p>