10.3389/fendo.2018.00088.s002
Hiroshige Sano
Hiroshige
Sano
Naoki Kondo
Naoki
Kondo
Taketoshi Shimakura
Taketoshi
Shimakura
Junichi Fujisawa
Junichi
Fujisawa
Yasufumi Kijima
Yasufumi
Kijima
Tomotake Kanai
Tomotake
Kanai
Kenneth E. S. Poole
Kenneth
E. S. Poole
Noriaki Yamamoto
Noriaki
Yamamoto
Hideaki E. Takahashi
Hideaki E.
Takahashi
Naoto Endo
Naoto
Endo
video_1.mp4
Frontiers
2018
modeling-based bone formation
forming minimodeling structures
femoral head
bone histomorphometry
femoral neck fracture
rheumatoid arthritis
hip osteoarthritis
2018-03-19 12:52:35
Media
https://frontiersin.figshare.com/articles/media/video_1_mp4/5999465
<p>Bone modeling is a biological process of bone formation that adapts bone size and shape to mechanical loads, especially during childhood and adolescence. Bone modeling in cortical bone can be easily detected using sequential radiographic images, while its assessment in trabecular bone is challenging. Here, we performed histomorphometric analysis in 21 bone specimens from biopsies collected during hip arthroplasty, and we proposed the criteria for histologically identifying an active modeling-based bone formation, which we call a “forming minimodeling structure” (FMiS). Evidence of FMiSs was found in 9 of 20 specimens (45%). In histomorphometric analysis, bone volume was significant higher in specimens displaying FMiSs compared with the specimens without these structures (BV/TV, 31.7 ± 10.2 vs. 23.1 ± 3.9%; p < 0.05). Osteoid parameters were raised in FMiS-containing bone specimens (OV/BV, 2.1 ± 1.6 vs. 0.6 ± 0.3%; p < 0.001, OS/BS, 23.6 ± 15.5 vs. 7.6 ± 4.2%; p < 0.001, and O.Th, 7.4 µm ± 2.0 vs. 5.2 ± 1.0; p < 0.05). Our results showed that the modeling-based bone formation on trabecular bone surfaces occurs even during adulthood. As FMiSs can represent histological evidence of modeling-based bone formation, understanding of this physiology in relation to bone homeostasis is crucial.</p>