10.3389/fimmu.2018.00352.s005
JooYeon Jhun
JooYeon
Jhun
Seung Hoon Lee
Seung
Hoon Lee
Soon Kyu Lee
Soon Kyu
Lee
Hee Yeon Kim
Hee Yeon
Kim
Eun Sun Jung
Eun
Sun Jung
Dong Goo Kim
Dong Goo
Kim
JeongWon Choi
JeongWon
Choi
Si Hyun Bae
Si
Hyun Bae
Seung Kew Yoon
Seung Kew
Yoon
Byung Ha Chung
Byung
Ha Chung
Chul Woo Yang
Chul
Woo Yang
Mi-La Cho
Mi-La
Cho
Jong Young Choi
Jong Young
Choi
table_1.docx
Frontiers
2018
regulatory T cell
T helper 17 cell
liver transplantation
tolerance
immunosuppression
2018-03-01 04:04:17
Dataset
https://frontiersin.figshare.com/articles/dataset/table_1_docx/5936923
<p>Recipients of liver transplantation (LT) require long-term immunosuppressive drug treatment, but lifelong immunosuppressive treatment has severe side effects. It is known that some LT recipients develop immune tolerance, and although the development of such operational tolerance should allow a decrease in the burden of immunosuppressive drug treatment, the factors that indicate operational tolerance are not clear. This study aimed to monitor immunological markers over time in LT recipients to identify those markers indicating the development of operational tolerance. We performed a prospective pilot study measuring immune markers, including the ratio of regulatory T (Treg) and T helper (Th) 17 cells in peripheral blood in the 14 most immunologically stable patients among 70 clinically stable LT recipients. The doses of immunosuppressive drugs given to these 14 LT recipients were tapered over time and they were monitored for immunological markers related to the development of immune tolerance. As the doses of immunosuppressive drugs were reduced, the Treg/Th17, Th1/Th17, and CD8/Th17 ratio in tolerant recipients was significantly increased compared with that of nontolerant recipients. These results suggest that monitoring of changes in the immune makers, including Treg/Th17 ratio during tapering of immunosuppression may allow prediction of the development of tolerance.</p>