Table_1.DOCX Qun Li Hong Wang Yanmei Xu Xiangning Bai Jianping Wang Zhengdong Zhang Xiang Liu Yimao Miao Ling Zhang Xinqiong Li Nianli Zou Guodong Yan Xi Chen Jie Zhang Shanshan Fu Ruyue Fan Jianguo Xu Juan Li Yanwen Xiong 10.3389/fmicb.2018.00258.s002 https://frontiersin.figshare.com/articles/dataset/Table_1_DOCX/5896192 <p>Escherichia albertii is an emerging member of the Enterobacteriaceae causing human and animal enteric infections. Antimicrobial resistance among enteropathogens has been reported to be increasing in the past years. The purpose of this study was to investigate antibiotic resistance and resistance genes in E. albertii isolated from Zigong city, Sichuan province, China. The susceptibility to 21 antimicrobial agents was determined by Kirby–Bauer disk diffusion method. The highest prevalence was tetracycline resistance with a rate of 62.7%, followed by resistance to nalidixic acid and streptomycin with a rate of 56.9 and 51.0%, respectively. All isolates were sensitive or intermediate susceptible to imipenem, meropenem, amoxicillin–clavulanic acid, and levofloxacin. Among 51 E. albertii isolates, 15 were extended-spectrum β-lactamase-producing as confirmed by the double disk test. The main β-lactamase gene groups, i.e., bla<sub>TEM</sub>, bla<sub>SHV</sub>, and bla<sub>CTX-M</sub>, were detected in17, 20, and 22 isolates, respectively. Furthermore, four colistin-resistant isolates with minimum inhibitory concentrations of 8 mg/L were identified. The colistin-resistant isolates all harbored mcr-1 and bla<sub>CTX-M-55</sub>. Genome sequencing showed that E. albertii strain SP140150 carried mcr-1 and bla<sub>CTX-M-55</sub> in two different plasmids. This study provided significant information regarding antibiotic resistance profiles and identified the co-occurrence of β-lactamase and MCR-1 encoding genes in E. albertii isolates.</p> 2018-02-16 04:21:19 Escherichia albertii β-lactam β-lactamases ESBL mcr-1