%0 Figure %A Jo, Si Yeon %A Kim, Mi Hye %A Lee, Haesu %A Lee, Sun Haeng %A Yang, Woong Mo %D 2020 %T Image_2_Ameliorative and Synergic Effects of Derma-H, a New Herbal Formula, on Allergic Contact Dermatitis.tif %U https://frontiersin.figshare.com/articles/figure/Image_2_Ameliorative_and_Synergic_Effects_of_Derma-H_a_New_Herbal_Formula_on_Allergic_Contact_Dermatitis_tif/12650003 %R 10.3389/fphar.2020.01019.s004 %2 https://frontiersin.figshare.com/ndownloader/files/23841611 %K allergic contact dermatitis %K Astragalus membranaceus Fisch. ex Bunge %K Nepeta tenuifolia Benth %K pruritus %K inflammation %X

Allergic contact dermatitis (ACD) is characterized by itching, skin inflammation, and allergic responses caused by release of immunoglobulin E and T helper 2-specific cytokines. The aim of this study is to investigate the ameliorative and synergic effects of herbal formula, Derma-H, containing Astragalus membranaceus Fisch. ex Bunge (AM) and Nepeta tenuifolia Benth (NT) which have been used as traditional medicinal herbs for the cure of dryness, edema, and pruritus. 2,4-Dinitrochlorobenzene (DNCB) was applied for ACD induction. AM, NT, and a mixture of AM and NT was topically applied to skin lesions for 11 days. Dermatitis score and number of scratches were significantly diminished in AM, NT, and AM + NT (Derma-H)-treated groups. Especially, Derma-H was more effective than single treatment of AM and NT on skin hyperplasia and mast cell infiltration. Also, NGF expression decreased by NT and a mixture of AM and NT. Additionally, series of TrkA, Raf-1, MEK, and ERK were significantly inhibited by topical AM and NT application. Those findings suggested AM and NT treatment has a synergic effect on DNCB-induced ACD in mice.

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