10.3389/fcell.2020.00438.s001
Yaxing Zhang
Yaxing
Zhang
Jing Wang
Jing
Wang
Yungang Ding
Yungang
Ding
Jiongshan Zhang
Jiongshan
Zhang
Yan Xu
Yan
Xu
Jingting Xu
Jingting
Xu
Shuhui Zheng
Shuhui
Zheng
Hongzhi Yang
Hongzhi
Yang
Table_1_Migrasome and Tetraspanins in Vascular Homeostasis: Concept, Present, and Future.DOCX
Frontiers
2020
cell migration
migrasome
migracytosis
tetraspanins
vascular homeostasis
2020-06-16 04:20:48
Dataset
https://frontiersin.figshare.com/articles/dataset/Table_1_Migrasome_and_Tetraspanins_in_Vascular_Homeostasis_Concept_Present_and_Future_DOCX/12487703
<p>Cell migration plays a critical role in vascular homeostasis. Under noxious stimuli, endothelial cells (ECs) migration always contributes to vascular repair, while enhanced migration of vascular smooth muscle cells (VSMCs) will lead to pathological vascular remodeling. Moreover, vascular activities are involved in communication between ECs and VSMCs, between ECs and immune cells, et al. Recently, Ma et al. (2015) discovered a novel migration-dependent organelle “migrasome,” which mediated release of cytoplasmic contents, and this process was defined as “migracytosis.” The formation of migrasome is precisely regulated by tetraspanins (TSPANs), cholesterol and integrins. Migrasomes can be taken up by neighboring cells, and migrasomes are distributed in many kinds of cells and tissues, such as in blood vessel, human serum, and in ischemic brain of human and mouse. In addition, the migrasome elements TSPANs are wildly expressed in cardiovascular system. Therefore, TSPANs, migrasomes and migracytosis might play essential roles in regulating vascular homeostasis. In this review, we will discuss the discoveries of migration-dependent migrasome and migracytosis, migrasome formation, the basic differences between migrasomes and exosomes, the distributions and functions of migrasome, the functions of migrasome elements TSPANs in vascular biology, and discuss the possible roles of migrasomes and migracytosis in vascular homeostasis.</p>