10.3389/fmicb.2020.00856.s004 Ling Shen Ling Shen Mengting Liu Mengting Liu Yan He Yan He Weaam Hasan Al Anbari Weaam Hasan Al Anbari Huaqiang Li Huaqiang Li Shuang Lin Shuang Lin Chenwei Chai Chenwei Chai Jianping Wang Jianping Wang Zhengxi Hu Zhengxi Hu Yonghui Zhang Yonghui Zhang Data_Sheet_4_Novel Antimicrobial Compounds as Ophiobolin-Type Sesterterpenes and Pimarane-Type Diterpene From Bipolaris Species TJ403-B1.ZIP Frontiers 2020 Bipolaris species TJ403-B1 ophiobolin-type sesterterpenes pimarane-type diterpene structure elucidation antimicrobial activity 2020-05-29 11:55:59 Dataset https://frontiersin.figshare.com/articles/dataset/Data_Sheet_4_Novel_Antimicrobial_Compounds_as_Ophiobolin-Type_Sesterterpenes_and_Pimarane-Type_Diterpene_From_Bipolaris_Species_TJ403-B1_ZIP/12388241 <p>Six previously undescribed ophiobolin-type sesterterpenes, namely, bipolatoxins A–F (1–6); and one previously undescribed pimarane-type diterpene, namely, 1β-hydroxy momilactone A (7); together with three known compounds, namely, 25-hydroxyophiobolin I (8), ophiobolin I (9), and ophiobolin A lactone (10); were isolated and identified from the endophytic fungus Bipolaris species TJ403-B1. Their structures with absolute configurations were elucidated on the basis of extensive spectroscopic analyses (including 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy data), single-crystal X-ray diffraction analyses, and comparison of experimental circular dichroism data. All compounds (except for 5) were evaluated for antimicrobial potential, which indicated that bipolatoxin D (4) showed significant inhibitory activity against Enterococcus faecalis with a minimum inhibitory concentration (MIC) value of 8 μg/mL, and ophiobolin A lactone (10) showed significant inhibitory activity against Acinetobacter baumannii and E. faecalis with MIC values of 8 and 8 μg/mL, respectively.</p>