10.3389/fmicb.2020.00856.s004
Ling Shen
Ling
Shen
Mengting Liu
Mengting
Liu
Yan He
Yan
He
Weaam Hasan Al Anbari
Weaam Hasan Al
Anbari
Huaqiang Li
Huaqiang
Li
Shuang Lin
Shuang
Lin
Chenwei Chai
Chenwei
Chai
Jianping Wang
Jianping
Wang
Zhengxi Hu
Zhengxi
Hu
Yonghui Zhang
Yonghui
Zhang
Data_Sheet_4_Novel Antimicrobial Compounds as Ophiobolin-Type Sesterterpenes and Pimarane-Type Diterpene From Bipolaris Species TJ403-B1.ZIP
Frontiers
2020
Bipolaris species TJ403-B1
ophiobolin-type sesterterpenes
pimarane-type diterpene
structure elucidation
antimicrobial activity
2020-05-29 11:55:59
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_4_Novel_Antimicrobial_Compounds_as_Ophiobolin-Type_Sesterterpenes_and_Pimarane-Type_Diterpene_From_Bipolaris_Species_TJ403-B1_ZIP/12388241
<p>Six previously undescribed ophiobolin-type sesterterpenes, namely, bipolatoxins A–F (1–6); and one previously undescribed pimarane-type diterpene, namely, 1β-hydroxy momilactone A (7); together with three known compounds, namely, 25-hydroxyophiobolin I (8), ophiobolin I (9), and ophiobolin A lactone (10); were isolated and identified from the endophytic fungus Bipolaris species TJ403-B1. Their structures with absolute configurations were elucidated on the basis of extensive spectroscopic analyses (including 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy data), single-crystal X-ray diffraction analyses, and comparison of experimental circular dichroism data. All compounds (except for 5) were evaluated for antimicrobial potential, which indicated that bipolatoxin D (4) showed significant inhibitory activity against Enterococcus faecalis with a minimum inhibitory concentration (MIC) value of 8 μg/mL, and ophiobolin A lactone (10) showed significant inhibitory activity against Acinetobacter baumannii and E. faecalis with MIC values of 8 and 8 μg/mL, respectively.</p>