10.3389/fped.2020.00233.s001
Noriko Motoki
Noriko
Motoki
Masaru Mizuki
Masaru
Mizuki
Teruomi Tsukahara
Teruomi
Tsukahara
Momoko Miyakawa
Momoko
Miyakawa
Shutaro Kubo
Shutaro
Kubo
Hirotsugu Oda
Hirotsugu
Oda
Miyuki Tanaka
Miyuki
Tanaka
Koji Yamauchi
Koji
Yamauchi
Fumiaki Abe
Fumiaki
Abe
Tetsuo Nomiyama
Tetsuo
Nomiyama
Data_Sheet_1_Effects of Lactoferrin-Fortified Formula on Acute Gastrointestinal Symptoms in Children Aged 12–32 Months: A Randomized, Double-Blind, Placebo-Controlled Trial.docx
Frontiers
2020
lactoferrin
infectious disease
diarrhea
growing-up formula
children
2020-05-19 13:05:54
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Effects_of_Lactoferrin-Fortified_Formula_on_Acute_Gastrointestinal_Symptoms_in_Children_Aged_12_32_Months_A_Randomized_Double-Blind_Placebo-Controlled_Trial_docx/12327704
<p>Objective: We investigated the effects of lactoferrin (LF)-fortified formula on acute gastrointestinal and respiratory symptoms in children.</p><p>Design: Randomized, double-blind, placebo-controlled trial.</p><p>Setting and subjects: Children aged 12–32 months in Japan.</p><p>Intervention: Intake of placebo or LF (48 mg/day)-fortified formula for 13 weeks.</p><p>Primary endpoint: Prevalence of acute gastrointestinal and respiratory symptom.</p><p>Results: One hundred nine participants were randomized. Eight participants were lost to follow-up, withdrew consent, or were deemed inappropriate for the trial, with 101 participants receiving complete analyses (placebo group, n = 48; LF group, n = 53).</p><p>Outcomes: The prevalence of acute gastrointestinal symptoms was significantly less in the LF group (22/53 [41.5%]) than in the placebo group (30/48 [62.5%], p = 0.046). The total number of days having acute respiratory symptoms was significantly lower in the LF group (9.0) than in the placebo group (15.0, p = 0.030).</p><p>Harms: The rate of adverse events was similar between the groups. No adverse drug reactions were found.</p><p>Conclusions: LF intake decreased the prevalence of acute gastrointestinal symptoms in children aged 12–32 months.</p>