10.3389/fcell.2020.00226.s003 Jessica Day Jessica Day Sophia Otto Sophia Otto Kathy Cash Kathy Cash Preethi Eldi Preethi Eldi Pravin Hissaria Pravin Hissaria Susanna Proudman Susanna Proudman Vidya Limaye Vidya Limaye John D. Hayball John D. Hayball Table_1_Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies.DOCX Frontiers 2020 myositis idiopathic inflammatory myopathy HMGB1 immune-mediated necrotising myopathy immune-mediated necrotizing myopathy inclusion body myositis necrotising autoimmune myopathy necrotizing autoimmune myopathy 2020-04-17 04:07:00 Dataset https://frontiersin.figshare.com/articles/dataset/Table_1_Aberrant_Expression_of_High_Mobility_Group_Box_Protein_1_in_the_Idiopathic_Inflammatory_Myopathies_DOCX/12142758 Introduction<p>High Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus. We postulate aberrant HMGB1 expression in immune-mediated necrotising myopathy (IMNM).</p>Methods<p>Herein, we compare HMGB1 expression (serological and sarcoplasmic) in patients with IMNM with that of other myositis subtypes using immunohistochemistry and ELISA.</p>Results<p>IMNM (n = 62) and inclusion body myositis (IBM, n = 14) patients had increased sarcoplasmic HMGB1 compared with other myositis patients (n = 46). Sarcoplasmic HMGB1 expression correlated with muscle weakness and histological myonecrosis, inflammation, regeneration and autophagy. Serum HMGB1 levels were elevated in patients with IMNM, dermatomyositis and polymositis, and those myositis patients with extramuscular inflammatory features.</p>Discussion<p>Aberrant HMGB1 expression occurs in myositis patients and correlates with weakness. A unique expression profile of elevated sarcoplasmic and serum HMGB1 was detected in IMNM.</p>