10.3389/fcell.2020.00226.s003
Jessica Day
Jessica
Day
Sophia Otto
Sophia
Otto
Kathy Cash
Kathy
Cash
Preethi Eldi
Preethi
Eldi
Pravin Hissaria
Pravin
Hissaria
Susanna Proudman
Susanna
Proudman
Vidya Limaye
Vidya
Limaye
John D. Hayball
John D.
Hayball
Table_1_Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies.DOCX
Frontiers
2020
myositis
idiopathic inflammatory myopathy
HMGB1
immune-mediated necrotising myopathy
immune-mediated necrotizing myopathy
inclusion body myositis
necrotising autoimmune myopathy
necrotizing autoimmune myopathy
2020-04-17 04:07:00
Dataset
https://frontiersin.figshare.com/articles/dataset/Table_1_Aberrant_Expression_of_High_Mobility_Group_Box_Protein_1_in_the_Idiopathic_Inflammatory_Myopathies_DOCX/12142758
Introduction<p>High Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus. We postulate aberrant HMGB1 expression in immune-mediated necrotising myopathy (IMNM).</p>Methods<p>Herein, we compare HMGB1 expression (serological and sarcoplasmic) in patients with IMNM with that of other myositis subtypes using immunohistochemistry and ELISA.</p>Results<p>IMNM (n = 62) and inclusion body myositis (IBM, n = 14) patients had increased sarcoplasmic HMGB1 compared with other myositis patients (n = 46). Sarcoplasmic HMGB1 expression correlated with muscle weakness and histological myonecrosis, inflammation, regeneration and autophagy. Serum HMGB1 levels were elevated in patients with IMNM, dermatomyositis and polymositis, and those myositis patients with extramuscular inflammatory features.</p>Discussion<p>Aberrant HMGB1 expression occurs in myositis patients and correlates with weakness. A unique expression profile of elevated sarcoplasmic and serum HMGB1 was detected in IMNM.</p>