10.3389/fmicb.2020.00422.s007
Rui Pang
Rui
Pang
Shi Wu
Shi
Wu
Feng Zhang
Feng
Zhang
Jiahui Huang
Jiahui
Huang
Haoming Wu
Haoming
Wu
Junhui Zhang
Junhui
Zhang
Yanping Li
Yanping
Li
Yu Ding
Yu
Ding
Jumei Zhang
Jumei
Zhang
Moutong Chen
Moutong
Chen
Xianhu Wei
Xianhu
Wei
Youxiong Zhang
Youxiong
Zhang
Qihui Gu
Qihui
Gu
Zhenwen Zhou
Zhenwen
Zhou
Bingshao Liang
Bingshao
Liang
Wenzhi Li
Wenzhi
Li
Qingping Wu
Qingping
Wu
Table_3_The Genomic Context for the Evolution and Transmission of Community-Associated Staphylococcus aureus ST59 Through the Food Chain.XLSX
Frontiers
2020
Staphylococcus aureus
molecular evolution
ST59 lineage
transmission
food chain
2020-03-17 04:30:40
Dataset
https://frontiersin.figshare.com/articles/dataset/Table_3_The_Genomic_Context_for_the_Evolution_and_Transmission_of_Community-Associated_Staphylococcus_aureus_ST59_Through_the_Food_Chain_XLSX/11992032
<p>Sequence type 59 (ST59) is a predominant clonal lineage of community-acquired, methicillin-resistant Staphylococcus aureus (CA-MRSA) in Asia. Despite its increasing clinical relevance in China, the evolution and geographic expansion of ST59 has been relatively uncared for. Previous study has shown that ST59 was the predominant clone in food-related MRSA in China. This study compared the genomes of 87 clonal complex (CC) 59 S. aureus isolates sourced from food chain and infection cases to reconstruct the molecular evolution and geographical spread of ST59. Accordingly, three major sub-clades of ST59 were identified and these did not correlate with isolation source or location. Phylogenetic analysis estimated that ST59 in mainland China diverged from a most common recent ancestor around 1974, and most of the cases of cross-country transmission occurred between 1987 and 2000. Notably, two recent events of cross-country transmission through the food chain were observed, the isolates from these events diverged within relatively short time intervals. These isolates also showed high similarity in terms of their core genome, accessory genes, and antibiotic resistance patterns. These findings provide a valuable insight into the potential route of ST59 expansion in China and indicate a need for robust food chain surveillance to prevent the spread of this pathogen.</p>